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Description: Ursodeoxycholic acid is an epimer of chenodeoxycholic acid. It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic.
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Ursodiol (also known as ursodeoxycholic acid) is one of the secondary bile acids, which are metabolic byproducts of intestinal bacteria. Primary bile acids are produced by the liver and stored in the gall bladder. When secreted into the colon, primary bile acids can be metabolized into secondary bile acids by intestinal bacteria. Primary and secondary bile acids help the body digest fats. Ursodeoxycholic acid helps regulate cholesterol by reducing the rate at which the intestine absorbs cholesterol molecules while breaking up micelles containing cholesterol. Because of this property, ursodeoxycholic acid is used to treat gall stones non-surgically.
Mechanism of Action: Ursodeoxycholic acid reduces elevated liver enzyme levels by facilitating bile flow through the liver and protecting liver cells.
Indication: Used to treat gall stones non-surgically.
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Data Correlations | 1 study

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Genes category icon Genes
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UBE2O 100 100
ASTN2 99 99
KIF15 98 98
SNF1LK 98 98
CUL7 94 94
UBE3B 94 94
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Biogroups category icon Biogroups
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Protein of unknown function GLTT 100 100
Aspartic proteases 100 100
Reelin Signaling Pathway 98 98
Leucine-rich repeat, typical subtyp… 97 97
NO2-dependent IL 12 Pathway in NK c… 97 97
SET Protein Family 97 97
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Individual Studies

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving ursodeoxycholic acid.

View All Author iconAuthors
  • Clifford J Steer
  • Hanns-Ulrich Marschall
  • Michael Trauner
  • Peter Fickert
  • Andrea Fuchsbichler
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDD…
  • Mayo Clinic
  • FDA Office of Orphan Products Development
  • University of Florida
  • National Center for Research Resources (NCRR)
View All Affiliations icon Organizations
  • University of Lisbon
  • Medical University Graz
  • Mayo Clinic and Foundation
  • Erasmus University Medical Center
  • Centre Hospitalier de l'Université de Montréal

Clinical Trials | 48 trials

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