Melanocyte with inducible oncogenic receptor Xmrk stimulated with EGF

Mus musculus

Mouse melanocytes transfected with an inducible version of the oncogenic receptor Xmrk (i.e. HER-mrk), were starved for 72 h and afterwards stimulated with EGF. We compared cells stimulated for 15 minutes, 1 hr, 2 hr, 4 hr, 8 hr or 24 hr, respectively, to unstimulated cells.

Source: NextBio Library/Oncology

Total # Biosets: 6

Inhibition of IL-2 activation of Sez-4 cells by Jak kinase inhibitors

Homo sapiens

In this study we studied the effects of IL-2 on cells derived from the CD4+ cutaneous T-cell lymphoma (CTCL). The effects of the cytokine stimulation were Jak3- and Jak1-kinase dependent. These findings document the impact of IL-2 on malignant CD4+ T cells and also suggest a novel therapeutic approa…

Authors: Marzec Michal, Halasa Krzysztof, Kasprzycka Monika, Wysocka Maria, Liu Xiaobin, Tobias W John et al.

Organization: University of Pennsylvania Pathology 362…

Total # Biosets: 5