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Data Correlations | 12 studies

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Individual Studies

  • Inhibition of IL-2 activation of Sez-4 cells by Jak kinase inhibitors

    Homo sapiens Homo sapiens

    In this study we studied the effects of IL-2 on cells derived from the CD4+ cutaneous T-cell lymphoma (CTCL). The effects of the cytokine stimulation were Jak3- and Jak1-kinase dependent. These findings document the impact of IL-2 on malignant CD4+ T cells and also suggest a novel therapeutic approa…

    Authors: Marzec Michal, Halasa Krzysztof, Kasprzycka Monika, Wysocka Maria, Liu Xiaobin, Tobias W John et al.

    Organization: University of Pennsylvania Pathology 362…

    Total # Biosets: 5

  • V600E BRAF and RTK-activated cells upon MEK inhibition

    Homo sapiens Homo sapiens

    Cell lines growing in culture (n=12) and murine xenografts (n=2) were treated with the MEK inhibitor PD0325901 or vehicle alone as control. Paired analysis of MEK inhibited to control samples was performed for two groups of tumor cells, V600E BRAF and RTK.

    Authors: Pratilas A Christine, Taylor S Barry

    Organization: Memorial Sloan-Kettering Cancer Center M…

    Total # Biosets: 4

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Associated Researchers

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Thought leaders and organizations working on research involving tyrosine kinase inhibitor.

View All Author iconAuthors
  • Jorge Cortes
  • Susan O'Brien
  • Hagop Kantarjian
  • Giovanni Martinelli
  • Hagop M Kantarjian
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Pfizer
  • SuperGen
  • M.D. Anderson Cancer Center
  • Children's Oncology Group
  • Novartis
View All Affiliations icon Organizations
  • University of Texas M.D. Anderson Cancer Center
  • M. D. Anderson Cancer Center
  • Vanderbilt University School of Medicine
  • University of Bologna
  • Hebrew University

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