tyrosine(Melanin Synthesized From Tyr Substrate Catalyzed By Tyrosinase For 6 Hrs)

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Search Term: tyrosine (treatment: Melanin Synthesized From Tyr Substrate Catalyzed By Tyrosinase For 6 Hrs)

Overview

Description:	A non-essential amino acid. In animals it is synthesized from phenylalanine. It is also the precursor of epinephrine; thyroid hormones; and melanin. [PubChem]
Drug Type:	Small Molecule; Nutraceutical; Approved
Pharmacology:	Tyrosine is a nonessential amino acid synthesized in the body from phenylalanine. Tyrosine is critical for the production of the body's proteins, enzymes and muscle tissue. Tyrosine is a precursor to the neurotransmitters norepinephrine and dopamine. It can act as a mood elevator and an anti-depressant. It may improve memory and increase mental alertness. Tyrosine aids in the production of melanin and plays a critical role in the production of thyroxin (thyroid hormones). Tyrosine deficiencies are manifested by hypothyroidism, low blood pressure and low body temperature. Supplemental tyrosine has been used to reduce stress and combat narcolepsy and chronic fatigue.
Mechanism of Action:	Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the phenylalanine required goes into the production of tyrosine; if the diet is rich in tyrosine itself, the requirements for phenylalanine are reduced by about 50%. The mechanism of L-tyrosine's antidepressant activity can be accounted for by the precursor role of L-tyrosine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects.
Indication:	Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies.

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Data Correlations | 1 study

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Genes

Score

YCL025C

100

YIR028W

YHR136C

YMR145C

YNL079C

T11F9.4

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Biogroups

Score

Cell division/GTP binding protein

100

Streptomycin Biosynthesis

100

Inositol Phosphate Metabolism

Urea Cycle

Arginine C Pathway

Aminoacyl-tRNA synthetase, class I,…

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Individual Studies
Yeast growth using different nitrogen sources Saccharomyces cerevisiae \| RNA Expression We compared the transcriptomes of Saccharomyces cerevisiae cells growing under steady-state conditions on 21 unique sources of nitrogen. of all identified nitrogen-responding transcriptional controls according to the nitrogen source. Authors: Godard P, Urrestarazu A, Vissers S et al. Organization: Université Libre de Bruxelles IBMM Physi…

Individual Studies

Yeast growth using different nitrogen sources

Saccharomyces cerevisiae | RNA Expression

We compared the transcriptomes of Saccharomyces cerevisiae cells growing under steady-state conditions on 21 unique sources of nitrogen. of all identified nitrogen-responding transcriptional controls according to the nitrogen source.

Authors: Godard P, Urrestarazu A, Vissers S et al.

Organization: Université Libre de Bruxelles IBMM Physi…