NextBio

Help

A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associ...

View Complete Description



Data Correlations | 9 studies

Help for Data Correlations View All
Genes category icon Genes
Score Help
CCL2 100 100
IFNG 100 100
SLC11A1 100 100
IFNGR1 100 100
CD209 100 100
SP110 100 100
View Top Genes
Biogroups category icon Biogroups
Score Help
Cytokine Cytokine Receptor Interact… 100 100
Cytokine Network 99 99
Selective Expression of Chemokine R… 98 98
Small chemokine, interleukin-8-like 97 97
Dendritic Cells (DC) In Regulating … 97 97
4-1BB Pathway 97 97
View Top Biogroups

Individual Studies

  • DCs stimulated with Mycobacterium tuberculosis

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The inhibitory axis of PD-1 expressed on T cells and its ligands produced by APCs mediates T cell exhaustion in chronic viral infection. We asked whether temporality of the infectious process is decisive for regulation through PD-1/PD-Ligand and investigated its impact on chronic bacterial infection…

    Authors: Winau F, Hegasy G, Kaufmann SH et al.

    Organization: Max-Planck-Institute for Infection Biolo…

  • M. tuberculosis sigma factor E effects in human THP1 cells

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    omparison of responses to infections Mycobacterium tuberculosis (Mtb) is well adapted to survive in macrophages and usually subverts the bactericidal mechanisms of these professional phagocytes.

    Authors: Fontan Patricia, Aris M Virginie, Ghanny S Saleena et al.

    Organization: PHRI-UMNDJ Center For Applied Genomics S…
View All Individual Studies

Literature | 186,633 results

Help for Literature View All

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving tuberculosis.

View All Author iconAuthors
  • Stefan H E Kaufmann
  • Lalita Ramakrishnan
  • John A Innes
  • Christopher Dye
  • Steven A Porcelli
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Centers for Disease Control and Prevention
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • University of Oxford
  • National Taiwan University Hospital
  • University of Cape Town
View All Affiliations icon Organizations
  • Max Planck Institute for Infection Biology
  • Trudeau Institute
  • Imperial College London
  • University of London
  • Weill Cornell Medical College

News | 681 stories

Help for News View All

Community

Help for Community
View All NextBio Users | 9 people
NextBio Groups

  • No NextBio groups were found for “tuberculosis”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio