nutritional condition produced by a deficiency of thiamine in the diet, characterized by anorexia, irritability, and weight loss; later, patients experience weakness, peripheral neuropathy, headache, and tachycardia; in addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption.

Data Correlations | 1 study

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Genes	Score
TKTL1	100
TKT	99

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Biogroups	Score
Pentose Phosphate Pathway	100

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Individual Studies
OMIM - Psychotic disorder Homo sapiens |   Mutations/Phenotypic This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories. Source: NextBio Library/Mutation and Phenotypic data

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Literature | 49,515 results

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• Epilepsy in children with infantile thiamine deficiency.

  Authors: A Fattal-Valevski, A Bloch-Mimouni, S Kivity, E Heyman, A Brezner, R Strausberg, D Inbar, U Kramer, H Goldberg-Stern

  Neurology 2009 Sep 15

• Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model.

  Authors: Saravanan S Karuppagounder, Hui Xu, Qingli Shi, Lian H Chen, Steve Pedrini, David Pechman, Harriet Baker, M Flint Beal, Sam E Gandy, Gary E Gibson

  Neurobiology of aging 2009 Oct

Associated Researchers

Thought leaders and organizations working on research involving thiamine deficiency.

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• Roger F Butterworth
• Darren Navarro
• Paul Desjardins
• Claudia Zwingmann
• Alan S Hazell

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• St. Michael's Hospital, Toronto
• National Center for Complementary and Alternative Medicine (NCCAM)
• Institute of Tropical Medicine, Belgium
• International Centre for Diarrhoeal Disease Research, Bangladesh
• Kantonsspital Luzern

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• University of Montreal
• Universidade Federal de Minas Gerais
• Fudan University
• Tel Aviv University
• Weill Medical College of Cornell University at Burke Medical Research …

Clinical Trials | 22 trials

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• The Prevalence of Thiamin Deficiency in Ambulatory Patients With Heart Failure

  conditions: Heart Failure

  interventions: none

   

• Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure

  conditions: Heart Failure

  interventions: Thiamine ; Placebo

   

News | 4 stories

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• Cat Food Recall Due to Thiamine Deficiency

  WebMD. - December 02, 2009

• Bird population declines in northern Europe are explained by thiamine deficiency

  Science Centric. - July 14, 2009

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