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Description: A drug formerly used as an antipsychotic but now used primarily in the treatment of various movement disorders including tardive dyskinesia. Tetrabenazine blocks uptake into adrenergic storage vesicles and has been used as a high affinity label for the vesicle transport system. [PubChem]
Drug Type: Small Molecule; Approved
Mechanism of Action: Tetrabenazine works mainly as a VMAT-inhibitor and as such promotes the early metabolic degradation of the neurotransmitter dopamine.
Indication: For the symptomatical treatment of hyperkinetic movement disorder.
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Data Correlations | 3 studies

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Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Liver Pharmacology and Xenobiotic Response Repertoire

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology.

    Authors: Natsoulis G, Pearson CI, Gollub J et al.

    Organization: Iconix Biosciences 325 E. Middlefield Rd…
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Associated Researchers

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Thought leaders and organizations working on research involving tetrabenazine.

View All Author iconAuthors
  • Joseph Jankovic
  • Christopher Kenney
  • Christine Hunter
  • William G Ondo
  • Arnold E Ruoho
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • NeuroSearch A/S
  • Centre for Addiction and Mental Health
  • Baylor College of Medicine
  • Prestwick Pharmaceuticals
  • Assistance Publique - Hôpitaux de Paris
View All Affiliations icon Organizations
  • Baylor College of Medicine
  • Università Cattolica del Sacro Cuore
  • Tel Aviv University
  • Universidad de La Laguna
  • University Hospital of Bellvitge

Clinical Trials | 11 trials

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Community

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