NextBio

Help
Description: Telithromycin is a semi-synthetic erythromycin derivative. It is used to treat mild to moderate respiratory infections. Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and blocks the progression of the growing polypeptide chain. In addition, telithromycin binds simultaneously to two domains of 23S RNA of the 50 S ribosomal subunit, where older macrolides bind only to one.
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Telithromycin is a macrolide antibiotic which has an antimicrobial spectrum similar or slightly wider to that of penicillin, and is often used for people who have an allergy to penicillins. For respiratory tract infections, it has better coverage of atypical organisms, including mycoplasma. It is also used to treat outbreaks of chlamydia, syphilis, and gonorrhea. Telithromycin prevents bacteria from growing, by interfering with their protein synthesis. Telithromycin binds to the subunit 50S of the bacterial ribosome, and thus inhibits the translocation of peptides.
Mechanism of Action: Telithromycin acts by binding to domains II and V of 23S rRNA of the 50S ribosomal subunit. By binding at domain II, telithromycin retains activity against gram-positive cocci (e.g., Streptococcus pneumoniae) in the presence of resistance mediated by methylases (erm genes) that alter the domain V binding site of telithromycin. Telithromycin may also inhibit the assembly of nascent ribosomal units.
Indication: For the treatment of Pneumococcal infection, acute sinusitis, acute bacterial tonsillitis, acute bronchitis and bronchiolitis, lower respiratory tract infection and lobar (pneumococcal) pneumonia.
Half Life: 10 hours
View Complete Description



Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving telithromycin.

View All Author iconAuthors
  • David J Farrell
  • Myung G Lee
  • Joo H Lee
  • Christian Joukhadar
  • Jun Shi
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Sanofi-Aventis
  • University of Pennsylvania
  • CPL Associates
  • University of Chicago
  • University of Illinois
View All Affiliations icon Organizations
  • Seoul National University
  • Medical University of Vienna
  • Carolinas Medical Center
  • National Public Health Institute
  • University of Würzburg

Clinical Trials | 98 trials

Help for Clinical Trials View All

Community

Help for Community
NextBio Users

  • No NextBio users were found for “telithromycin”.
    Complete your user profile with your interests, if you want others to find you within the NextBio community.

NextBio Groups

  • No NextBio groups were found for “telithromycin”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio