Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate through direct electrical connections which are sometimes called electrical synapses.

Data Correlations | 2 studies

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Genes	Score
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Individual Studies

Identification of genes that are dysregulated in the telencephalon of Dlx1/2 mutants Mus musculus |   RNA Expression The Dlx homeodomain transcription factors are implicated in regulating the function of inhibitory neurons; therefore understanding their functions will provide insights into disorders such as epilepsy, mental retardation, autism and cerebral palsy. Authors: Rubenstein JL Organization: NIH Neuroscience Microarray Consortium N…

Study of synaptic function and neuroplasticity in incipient AD Homo sapiens |   RNA Expression To identify molecular targets downstream of oAβ binding we prepared synaptoneurosomes from frontal cortex of control and IAD patients, and isolated mRNAs for comparison of gene expression. Authors: Williams C, Mehrian Shai R, Wu Y et al. Organization: Keck School of Medicine, USC Pathology M…

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Literature | 58,765 results

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• Opioids block long-term potentiation of inhibitory synapses.

  Authors: Fereshteh S Nugent, Esther C Penick, Julie A Kauer

  Nature 2007 Apr 26

• Synapses: sites of cell recognition, adhesion, and functional specification.

  Authors: Soichiro Yamada, W James Nelson

  Annual review of biochemistry 2007

Associated Researchers

Thought leaders and organizations working on research involving synapse.

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• Thomas C Südhof
• Gillian M Griffiths
• Jane C Stinchcombe
• Gayane Aramuni
• Michael E Greenberg

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• National Institute of Neurological Disorders and Stroke (NINDS)
• National Institute of Mental Health (NIMH)
• Emory University
• University of Utah
• Synapse Biomedical

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• University of California
• Washington University School of Medicine
• Max Planck Institute of Experimental Medicine
• Sir William Dunn School of Pathology
• Picower Institute for Learning and Memory

Clinical Trials | 25 trials

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• Neuroimmunological Model of Traumatic Memory

  conditions: Stress Disorders, Post-Traumatic

  interventions: Blood test

   

• Investigation of Neuroserpin as an Autism Candidate Gene

  conditions: Autism

  interventions: none

   

News | 44 stories

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• Brain Cells Chat, Even Without a Synapse

  Science.

• Over 100,000 Canadian Youth Introduced To Science Through CIHR's Synapse Program

  Medical News Today. - October 13, 2009

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