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Description: A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Succinylcholine is indicated as an adjunct to general anesthesia, to facilitate tracheal intubation, and to provide skeletal muscle relaxation during surgery or mechanical ventilation. Succinylcholine is a depolarizing skeletal muscle relaxant. As does acetylcholine, it combines with the cholinergic receptors of the motor end plate to produce depolarization. This depolarization may be observed as fasciculations. Subsequent neuromuscular transmission is inhibited so long as adequate concentration of succinylcholine remains at the receptor site. Succinylcholine has no direct action on the uterus or other smooth muscle structures.
Mechanism of Action: The mechanism of action of Succinylcholine involves what appears to be a 'persistent' depolarization of the neuromuscular junction. This depolarization is caused by Succinylcholine mimicking the effect of acetylcholine but without being rapidly hydrolysed by acetylcholinesterase. This depolarization leads to desensitization.
Indication: Used in surgical procedures where a rapid onset and brief duration of muscle relaxation is needed (includes intubation, endoscopies, and ECT)
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Data Correlations | 1 study

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Genes category icon Genes
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CHRM1 100 100
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Biogroups category icon Biogroups
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Blockade of Neurotransmitter Relase… 100 100
G-Protein Signaling Through Tubby P… 100 100
Monoamine GPCRs 94 94
Actions of Nitric Oxide in the Hear… 93 93
Calcium Regulation In Cardiac Cells 91 91
Calcium Signaling Pathway 91 91
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Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Literature | 14,367 results

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Associated Researchers

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Thought leaders and organizations working on research involving suxamethonium.

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  • Mohamed Naguib
  • Saleh W Alharby
  • Jayaram R Tagat
  • Jay B Brodsky
  • Waleed Riad
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  • Mentor Corporation
  • Novartis
  • Organon
  • University Hospital, Basel, Switzerland
  • GlaxoSmithKline
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  • Schering-Plough Research Institute
  • University of California
  • Harbor-UCLA Medical Center
  • Christchurch School of Medicine
  • Centre Hospitalier Universitaire

Clinical Trials | 35 trials

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