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Description: An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Acitretin is a retinoid. Retinoids have a structure similar to vitamin A and are involved in the normal growth of skin cells. Acitretin works by inhibiting the excessive cell growth and keratinisation (process by which skin cells become thickened due to the deposition of a protein within them) seen in psoriasis. It therefore reduces the thickening of the skin, plaque formation and scaling.
Mechanism of Action: The mechanism of action of acitretin is unknown, however it is believed to work by targeting specific receptors (retinoid receptors) in the skin which help normalize the growth cycle of skin cells.
Indication: For the treatment of severe psoriasis in adults.
Half Life: 49 hours (range 33 to 96 hours)
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Data Correlations | 1 study

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Genes category icon Genes
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RXRG 100 100
RARG 99 99
RXRB 99 99
RXRA 98 98
RARB 98 98
RARA 97 97
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Biogroups category icon Biogroups
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Steroid hormone receptor 100 100
Nuclear Receptors 100 100
Zinc finger, nuclear hormone recept… 99 99
Nuclear hormone receptor, ligand-bi… 99 99
Nuclear hormone receptor, ligand-bi… 99 99
RAR-RXR Pathway 99 99
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Individual Studies

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    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving soriatane.

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  • Steven R Feldman
  • Daniel J Pearce
  • Brad A Yentzer
  • Rajesh Balkrishnan
  • Adele Clark
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Wyeth
  • Peplin
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • Innovaderm Research Inc.
  • National Cancer Institute (NCI)
View All Affiliations icon Organizations
  • Wake Forest University School of Medicine
  • National University of Singapore
  • University Medical Center
  • University of Bologna
  • Chang Gung Memorial Hospital

Clinical Trials | 47 trials

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