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A chronic disorder marked by hardening and thickening of the skin. Scleroderma can be localized or it can affect the entire body (systemic).

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Data Correlations | 5 studies

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Genes category icon Genes
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FBN1 100 100
Gt(ROSA)26Sor 100 100
COMP 100 100
IGHM 97 97
SFRP4 95 95
H2AFV 95 95
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Biogroups category icon Biogroups
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EGF calcium-binding 100 100
EGF-like calcium-binding 100 100
Concanavalin A-like lectin/glucanas… 100 100
Cell Communication 98 98
Focal Adhesion 98 98
EGF-like 97 97
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Individual Studies

  • TGF-beta1 effects on normal, IPF and fibrosing alveolitis lung cells

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The response to a 4 hour treatment with TGFbeta (4 ng/ml) was evaluated in lung fibroblasts derived from three controls (normal periphery of resected tumor), open lung biopsies from three patients with idiopathic pulmonary fibrosis (usual interstitial pneumonia pattern on biopsy) and from three pati…

    Authors: Renzoni A Elisabetta, Abraham J David, Howat Sarah et al.

    Organization: Royal Brompton Hospital/Imperial College…

  • SSc patients with diffuse scleroderma vs normal individuals

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Transcription profiling of human skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma vs biopsies from normal individuals.

    Source: NextBio Library/Injury & Inflammation
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Associated Researchers

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Thought leaders and organizations working on research involving scleroderma.

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  • Christopher P Denton
  • Daniel E Furst
  • Dinesh Khanna
  • Maureen D Mayes
  • Fredrick M Wigley
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Arthritis and Musculoskeletal and Skin Diseases …
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • Stanford University
  • MedImmune LLC
  • Northwestern University
View All Affiliations icon Organizations
  • Johns Hopkins University School of Medicine
  • Royal Free and University College Medical School
  • University of Western Ontario
  • University of Cincinnati
  • University of California, Los Angeles

News | 33 stories

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Community

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