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Description: A benzoic-sulfonamide-furan. It is a diuretic with fast onset and short duration that is used for edema and chronic renal insufficiency. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Furosemide, a sulfonamide-type loop diuretic structurally related to bumetanide, is used to manage hypertension and edema associated with congestive heart failure, cirrhosis, and renal disease, including the nephrotic syndrome.
Mechanism of Action: Furosemide, by inhibiting the reabsorption of sodium and chloride in the ascending limb of the loop of Henle, increases the urinary excretion of sodium, chloride, and water. Furosemide also increases the excretion of potassium, hydrogen, calcium, magnesium, ammonium, and phosphate and, as it inhibits carbonic anhydrase, bicarbonate.
Indication: For the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Also for the treatment of hypertension alone or in combination with other antihypertensive agents.
Half Life: 2 hours
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Data Correlations | 6 studies

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Genes category icon Genes
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SLC12A1 100 100
ATP1A1 100 100
ADRA2C 97 97
C16orf35 95 95
GNL3L 94 94
COQ7 93 93
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Biogroups category icon Biogroups
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Phospholipase A2, active site 100 100
Protein of unknown function GLTT 98 98
Cell surface antigen 97 97
Ganglioside Biosynthesis 96 96
Glycosylphosphatidylinositol Anchor… 95 95
Proepithelin Pathway 95 95
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Individual Studies

  • Microdissected kidney structure gene profiling using the MOE430 platform

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    Our laboratory's interest is in understanding the molecular principles that underlie the regional organization of the mammalian metanephric kidney. Our goal is to generate a detailed spatial map of the cellular expression of selected regulatory genes during mammalian kidney development. The goal of…

    Authors: McMahon P Andrew, Valerius T M

    Organization: MRC Human Genetics Unit Crewe Road Edinb…

  • Microdissected kidney structure gene profiling using the U74 platform

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    Our laboratory's interest is in understanding the molecular principles that underlie the regional organization of the mammalian metanephric kidney. Our goal is to generate a detailed spatial map of the cellular expression of selected regulatory genes during mammalian kidney development. The goal of…

    Authors: McMahon P Andrew, Valerius T M

    Organization: MRC Human Genetics Unit Crewe Road Edinb…
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Associated Researchers

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Thought leaders and organizations working on research involving salix.

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  • Pieter Vervaeke
  • Eric Messens
  • Loretta Pobłocka-Olech
  • Hanneke Huvenne
  • Timothy A Volk
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Mylan Pharmaceuticals
  • Rabin Medical Center
  • University of Alberta
  • Roxane Laboratories
  • Tottori University Hospital
View All Affiliations icon Organizations
  • Swedish University of Agricultural Sciences
  • State University of New York College of Environmental Science and Fore…
  • State University of New York
  • Medical University of Gdańsk
  • University of Hong Kong

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