risperidone - NextBio

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Search Term: risperidone (treatment)

Overview

Description:	A selective blocker of dopamine D2 receptors and serotonin 5-HT2 receptors that acts as an atypical antipsychotic agent. It has been shown to improve both positive and negative symptoms in the treatment of schizophrenia. [PubChem]
Drug Type:	Small Molecule; Approved; Investigational
Pharmacology:	Risperidone is an atypical antipsychotic medication. It is most often used to treat delusional psychosis (including schizophrenia), but risperidone is also used to treat some forms of bipolar disorder and psychotic depression. It also has shown some success in treating symptoms of Asperger's Syndrome and autism. Risperidone is now the most commonly prescribed antipsychotic medication in the United States.
Mechanism of Action:	Blockade of dopaminergic D2 receptors in the limbic system alleviates positive symptoms of schizophrenia such as hallucinations, delusions, and erratic behavior and speech. Blockade of serotonergic 5-HT2 receptors in the mesocortical tract, causes an excess of dopamine and an increase in dopamine transmission, resulting in an increase in dopamine transmission and an elimination of core negative symptoms. Dopamine receptors in the nigrostriatal pathway are not affected by risperidone and extrapyramidal effects are avoided. Like other 5-HT2 antagonists, risperidone also binds at alpha(1)-adrenergic receptors and, to a lesser extent, at histamine H1 and alpha(2)-adrenergic receptors.
Indication:	For the treatment of schizophrenia in adults and in adolescents, ages 13 to 17, and for the short-term treatment of manic or mixed episodes of bipolar I disorder in children and adolescents ages 10 to 17.
Half Life:	3 hours

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Data Correlations | 2 studies

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Genes

Score

HRH1

100

ADRB1

100

HTR2A

100

ADRA1A

100

DRD2

100

TOP3A

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Biogroups

Score

Neuroactive Ligand Receptor Interac…

100

G-alpha-I Pathway

100

Monoamine GPCRs

Kelch related

Tudor

I29 - cytotoxic T-lymphocyte antige…

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Individual Studies
Drug target sets for approved compounds Homo sapiens \| Therapeutic The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information. Authors: David S Wishart, Craig Knox, An Chi Guo et al. Organization: Department of Computing Science, Univers…	Broad Connectivity Map (CMAP 2.0) compound database Homo sapiens \| RNA Expression A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes. Authors: Lamb J Organization: Broad Institute Seven Cambridge Center C…

Individual Studies

Drug target sets for approved compounds

Homo sapiens | Therapeutic

The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

Authors: David S Wishart, Craig Knox, An Chi Guo et al.

Organization: Department of Computing Science, Univers…

Broad Connectivity Map (CMAP 2.0) compound database

Homo sapiens | RNA Expression

A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

Authors: Lamb J

Organization: Broad Institute Seven Cambridge Center C…