NextBio

Help
Description: A glutamate antagonist (receptors, glutamate) used as an anticonvulsant (anticonvulsants) and to prolong the survival of patients with amyotrophic lateral sclerosis. [PubChem]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Riluzole, a member of the benzothiazole class, is indicated for the treatment of patients with amyotrophic lateral sclerosis (ALS). Riluzole extends survival and/or time to tracheostomy. It is also neuroprotective in various in vivo experimental models of neuronal injury involving excitotoxic mechanisms. The etiology and pathogenesis of amyotrophic lateral sclerosis (ALS) are not known, although a number of hypotheses have been advanced. One hypothesis is that motor neurons, made vulnerable through either genetic predisposition or environmental factors, are injured by glutamate. In some cases of familial ALS the enzyme superoxide dismutase has been found to be defective.
Mechanism of Action: The mode of action of riluzole is unknown. Its pharmacological properties include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) ability to interfere with intracellular events that follow transmitter binding at excitatory amino acid receptors.
Indication: For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)
Half Life: The mean elimination half-life of riluzole is 12 hours (CV=35%) after repeated doses.
View Complete Description



Data Correlations | 2 studies

Help for Data Correlations View All
Genes category icon Genes
Score Help
SCN5A 100 100
GRIN3A 100 100
FGR 87 87
FLOT1 86 86
IER3 85 85
TWF1 84 84
View Top Genes
Biogroups category icon Biogroups
Score Help
Somatotropin hormone 100 100
Ganglioside Biosynthesis 93 93
SEA Protein Family 93 93
O-Glycan Biosynthesis 93 93
Peptidase M12B, propeptide 93 93
Type III Secretion System 93 93
View Top Biogroups

Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving riluzole.

View All Author iconAuthors
  • Gerard Sanacora
  • Sarah Vautier
  • Robert Farinotti
  • Christine Fernandez
  • Vincent Meininger
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Mental Health (NIMH)
  • Yale University
  • Sanofi-Aventis
  • Cancer Institute of New Jersey
  • Assistance Publique - Hôpitaux de Paris
View All Affiliations icon Organizations
  • University of Ulsan College of Medicine
  • National Institute of Mental Health
  • Mount Sinai School of Medicine
  • University of Ulm
  • Yale University School of Medicine

Clinical Trials | 73 trials

Help for Clinical Trials View All

News | 2 stories

Help for News View All

Community

Help for Community
NextBio Users

  • No NextBio users were found for “riluzole”.
    Complete your user profile with your interests, if you want others to find you within the NextBio community.

NextBio Groups

  • No NextBio groups were found for “riluzole”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio