resveratrol - NextBio

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Search Term: resveratrol (treatment)

Overview

Description:	Resveratrol (3,5,4'-trihydroxystilbene) is a polyphenolic phytoalexin. It is a stilbenoid, a derivate of stilbene, and is produced in plants with the help of the enzyme stilbene synthase. It exists as two structural isomers: cis-(Z) and trans-(E), with the trans-isomer shown in the top image. The trans- form can undergo isomerisation to the cis- form when heated or exposed to ultraviolet irradiation. In a 2004 issue of Science, Dr. Sinclair of Harvard University said resveratrol is not an easy molecule to protect from oxidation. It has been claimed that it is readily degraded by exposure to light, heat, and oxygen. However, studies find that Trans-resveratrol undergoes negligible oxidation in normal atmosphere at room temperature. [Wikipedia]
Drug Type:	Small Molecule; Experimental; Investigational
Pharmacology:	Resveratrol, a phytoalexin, has been found to inhibit herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) replication in a dose-dependent, reversible manner, although this is only one of its many pharmaceutical properties. In some countries where there is higher consumption of red wine, there appears to be a lower incidence of heart disease. Other benefits of resveratrol include its anti-inflammatory and antioxidant effects. In preclinical studies, Resveratrol has been found to have potential anticancer properties.
Mechanism of Action:	Resveratrol suppresses NF-kappaB (NF-kappaB) activation in HSV infected cells. Reports have indicated that HSV activates NF-kappaB during productive infection and this may be an essential aspect of its replication scheme [PMID: 9705914].
Indication:	Being investigated for the treatment of Herpes labialis infections (cold sores).

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Data Correlations | 6 studies

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Genes

Score

675521

100

PURB

Mup1

Hsd3b5

LIPA

C04G2.2

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Biogroups

Score

Valine Leucine and Isoleucine Degra…

100

Peptidase C19, ubiquitin carboxyl-t…

Nucleotide-binding, alpha-beta plai…

RNA recognition motif, RNP-1

Armadillo-type fold

Metabolism of Xenobiotics by Cytoch…

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Individual Studies
Resveratrol action on A549 lung cancer cells Homo sapiens \| RNA Expression Resveratrol, a natural phytoestrogen found in red wine and a variety of plants, is reported to have protective effects against lung cancer, however there is very little work directed towards the understanding of the mechanism of action of resveratrol in lung cancer. In this study we used an experim… Authors: Whyte L Lorna, Mehta G Ranjedra Organization: IIT Research Institute Division of Carci…	Liver from mice fed high-calorie diet or high calorie diet + resveratrol Mus musculus \| RNA Expression One-year-old male C57BL/6 mice were maintained on AIN-93G standard diet (SD), AIN-93G modified to provide 60% of calories from fat (HC), or HC diet with the addition of 0.04% resveratrol (HCR). Authors: Baur A Joseph, Pearson J Kevin, Price L Nathan et al. Organization: National Institute on Aging, NIH Researc…

Individual Studies

Resveratrol action on A549 lung cancer cells

Homo sapiens | RNA Expression

Resveratrol, a natural phytoestrogen found in red wine and a variety of plants, is reported to have protective effects against lung cancer, however there is very little work directed towards the understanding of the mechanism of action of resveratrol in lung cancer. In this study we used an experim…

Authors: Whyte L Lorna, Mehta G Ranjedra

Organization: IIT Research Institute Division of Carci…

Liver from mice fed high-calorie diet or high calorie diet + resveratrol

Mus musculus | RNA Expression

One-year-old male C57BL/6 mice were maintained on AIN-93G standard diet (SD), AIN-93G modified to provide 60% of calories from fat (HC), or HC diet with the addition of 0.04% resveratrol (HCR).

Authors: Baur A Joseph, Pearson J Kevin, Price L Nathan et al.

Organization: National Institute on Aging, NIH Researc…