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Description: A widely used non-cardioselective beta-adrenergic antagonist. Propranolol is used in the treatment or prevention of many disorders including acute myocardial infarction, arrhythmias, angina pectoris, hypertension, hypertensive emergencies, hyperthyroidism, migraine, pheochromocytoma, menopause, and anxiety. [PubChem]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Propranolol, the prototype of the beta-adrenergic receptor antagonists, is a competitive, nonselective beta-blocker similar to nadolol without intrinsic sympathomimetic activity. Propanolol is a racemic compound; the l-isomer is responsible for adrenergic blocking activity.
Mechanism of Action: Like atenolol and metoprolol, propranolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles.
Indication: For the prophylaxis of migraine.
Half Life: 4 hours
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Data Correlations | 2 studies

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Genes category icon Genes
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ADRB2 100 100
ADRB1 100 100
PSME4 99 99
TFIP11 93 93
ZNF440 91 91
C10orf18 90 90
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Biogroups category icon Biogroups
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Rhodopsin Like 100 100
Calcium Regulation In Cardiac Cells 100 100
Calcium Signaling Pathway 100 100
Neuroactive Ligand Receptor Interac… 99 99
FOSB Gene Expression and Drug Abuse 97 97
D111/G-patch 96 96
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Individual Studies

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    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

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    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving propranolol.

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  • Jaume Bosch
  • Juan G Abraldes
  • Ronei Jesus Poppi
  • Walter Everaerd
  • Patrícia Valderrama
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Mental Health (NIMH)
  • National Institute on Drug Abuse (NIDA)
  • Korea University
  • National Institute of Neurological Disorders and Stroke (NINDS)
  • Par Pharmaceutical, Inc.
View All Affiliations icon Organizations
  • University of São Paulo
  • Leiden University
  • University of Campinas
  • Vanderbilt University
  • Institute of Liver and Biliary Sciences

Clinical Trials | 167 trials

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