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Description: The prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubular excretion of other drugs, has been used as an adjunct to antibacterial therapy. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Probenecid is a uricosuric and renal tubular blocking agent and is used in combination with colchicine to treat chronic gouty arthritis when complicated by frequent, recurrent acute attacks of gout. It inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels. Effective uricosuria reduces the miscible urate pool, retards urate deposition, and promotes resorption of urate deposits.
Mechanism of Action: Probenecid inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels.
Indication: For the treatment of gout and high levels of uric acid in the blood
Half Life: 6-12 hours
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Data Correlations | 2 studies

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Genes category icon Genes
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SLC22A8 100 100
EIF5A 97 97
CASP2 93 93
FCF1 92 92
CXCL12 90 90
CPA4 88 88
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Biogroups category icon Biogroups
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Caspase Recruitment 100 100
MTA3 Pathway 99 99
Protein of unknown function DUF1220 98 98
PELP1 Pathway 98 98
Translation protein SH3-like 98 98
Dictyostelium Discoideum cAMP Chemo… 97 97
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Individual Studies

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    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

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    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving probenecid.

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  • Jürgen B Bulitta
  • Mark Holodniy
  • Dennis W Raisch
  • Ulrike Holzgrabe
  • Timothy M Straight
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  • National Institute of Allergy and Infectious Diseases (NIAID)
  • Gilead Sciences
  • Hoffmann-La Roche
  • Glaxo Wellcome
  • National Center for Research Resources (NCRR)
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  • University of Szeged
  • IBMP-Institute for Biomedical and Pharmaceutical Research
  • Kenya Medical Research Institute/Wellcome Trust Collaborative Research…
  • National Institute of Child Health and Human Development
  • Institut National de la Santé et de la Recherche Médicale

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