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Search Term: prednisolone (treatment)

Overview

Description:	A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states. [PubChem]
Drug Type:	Small Molecule; Approved
Pharmacology:	Prednisolone is a synthetic glucocorticoid used as antiinflammatory or immunosuppressive agent. Prednisolone is indicated in the treatment of various conditions, including congenital adrenal hyperplasia, psoriatic arthritis, systemic lupus erythematosus, bullous dermatitis herpetiformis, seasonal or perennial allergic rhinitis, allergic corneal marginal ulcers, symptomatic sarcoidosis, idiopathic thrombocytopenic purpura in adults, leukemias and lymphomas in adults, and ulcerative colitis. Glucocorticoids are adrenocortical steroids and cause profound and varied metabolic effects. In addition, they modify the body's immune responses to diverse stimuli.
Mechanism of Action:	Glucocorticoids such as Prednisolone can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The antiinflammatory actions of glucocorticoids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Prednisolone reduces inflammatory reaction by limiting the capillary dilatation and permeability of the vascular structures. These compounds restrict the accumulation of polymorphonuclear leukocytes and macrophages and reduce the release of vasoactive kinins. Recent research suggests that corticosteroids may inhibit the release of arachidonic acid from phospholipids, thereby reducing the formation of prostaglandins. Prednisolone is a glucocorticoid receptor agonist. On binding, the corticoreceptor-ligand complex translocates itself into the cell nucleus, where it binds to many glucocorticoid response elements (GRE) in the promoter region of the target genes. The DNA bound receptor then interacts with basic transcription factors, causing an increase or decrease in expression of specific target genes, including suppression of IL2 (interleukin 2) expression.
Indication:	For the treatment of primary or secondary adrenocortical insufficiency, such as congenital adrenal hyperplasia, thyroiditis. Also used to treat psoriatic arthritis, rheumatoid arthritis, ankylosing spondylitis, bursitis, acute gouty arthritis and epicondylitis. Also indicated for treatment of systemic lupus erythematosus, pemphigus and acute rhematic carditis. Can be used in the treatment of leukemias, lymphomas, thrombocytopenia purpura and autoimmune hemolytic anemia. Can be used to treat celiac disease, insulin resistance, ulcerative colitis and liver disorders.
Half Life:	2-3 hours

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Data Correlations | 40 studies

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Genes

Score

SERPINA6

100

100

RGD1563079_predicted

RGD1563275_predicted

EREG

GCK

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Biogroups

Score

I43 - oprin

100

Calcineurin Nf At Signaling

Selective Expression of Chemokine R…

Histone-fold

Natural Killer Cell Mediated Cytoto…

Rhodopsin Like

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Individual Studies
Dexamethasone-treated primary chondrocytes identify downstream targets of glucocorticoid signalling Mus musculus \| RNA Expression Background: Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation and decreased bone quality in adults. On a physiological level, GCs have been implicated in the regul… Authors: James CG, Ulici V, Tuckermann J et al. Organization: University of Western Ontario Physiology…	Microarray data following GR activation in MCF10A-Myc breast cells Homo sapiens \| RNA Expression This series contain time course microarray data from MCF10A-Myc cells treated with either ethanol or Dexamethasone for 30 min, 2 hr, 4 hr, and 24 hr. This series contains three biological replicates that were analyzed as independent replicate experiments (data were normalized within each replicate e… Authors: Min Z, Wu W, Brickley D et al. Organization: University of Chicago Medicine 5841 S. M…

Individual Studies

Dexamethasone-treated primary chondrocytes identify downstream targets of glucocorticoid signalling

Mus musculus | RNA Expression

Background: Glucocorticoids (GCs) are widely used anti-inflammatory drugs. While useful in clinical practice, patients taking GCs often suffer from skeletal side effects including growth retardation and decreased bone quality in adults. On a physiological level, GCs have been implicated in the regul…

Authors: James CG, Ulici V, Tuckermann J et al.

Organization: University of Western Ontario Physiology…

Microarray data following GR activation in MCF10A-Myc breast cells

Homo sapiens | RNA Expression

This series contain time course microarray data from MCF10A-Myc cells treated with either ethanol or Dexamethasone for 30 min, 2 hr, 4 hr, and 24 hr. This series contains three biological replicates that were analyzed as independent replicate experiments (data were normalized within each replicate e…

Authors: Min Z, Wu W, Brickley D et al.

Organization: University of Chicago Medicine 5841 S. M…