A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines. It arises from the chromaffin cells of the adrenal medulla. Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor. Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen. Other growth patterns including trabecular pattern may also be present.

Data Correlations | 6 studies

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Genes	Score
RET	100
VHL	100
SDHD	100
SDHB	100
SDHC	100
GDNF	100

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Biogroups	Score
VEGF, Hypoxia, and Angiogenesis	100
Hypoxia-inducible Factor In The Car…	99
Oxidative Phosphorylation	98
Electron Transport Reaction In Mito…	96
Benzoate Degradation Via Coa Ligati…	93
Citrate Cycle	93

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Individual Studies

Effect of Trimethyltin on PC12 cells Rattus norvegicus |   RNA Expression The rat pheochromocytoma cell line PC12 cells were cultured in complete DMEM till 80% confluence, then placed at 5000 cells per squared cm. Cells were then plated in 24-well plates for cell viability assay and in T75 flasks for RNA isolation. Medium was replaced with serum-free fresh medium for 12 … Authors: Bernardini Camilla, Lattanzi Wanda Organization: UCSC Human Anatomy L.go F.Vito 1 Rome 00…

Expression profiling of pheochromocytomas of various genetic origins Homo sapiens |   RNA Expression Pheochromocytomas are neural crest-derived tumors that arise from inherited or sporadic mutations in at least six independent genes: RET, VHL, NF1, and subunits B, C and D of succinate dehydrogenase (SDH). The proteins encoded by these multiple genes regulate distinct functions. To identify molecula… Authors: Dahia PL, Ross KN, Wright ME et al. Organization: Dana-Farber Cancer Institute 1 Jimmy Fun…

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Literature | 17,975 results

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• Germline mutations in TMEM127 confer susceptibility to pheochromocytoma.

  Authors: Yuejuan Qin, Li Yao, Elizabeth E King, Kalyan Buddavarapu, Romina E Lenci, E Sandra Chocron, James D Lechleiter, Meghan Sass, Neil Aronin, Francesca Schiavi,…

  Nature genetics 2010 Mar

• Brief communication: radiographic contrast infusion and catecholamine release in patients with pheochromocytoma.

  Authors: Smita K Baid, Edwin W Lai, Robert A Wesley, Alex Ling, Henri J L M Timmers, Karen T Adams, Anna Kozupa, Karel Pacak

  Annals of internal medicine 2009 Jan 6

Associated Researchers

Thought leaders and organizations working on research involving pheochromocytoma.

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• Karel Pacak
• Graeme Eisenhofer
• Ronald R de Krijger
• Patricia L M Dahia
• Henri J L M Timmers

View All Clinical Trials Sponsors

• Molecular Insight Pharmaceuticals, Inc.
• National Cancer Institute (NCI)
• Sanofi-Aventis
• Eunice Kennedy Shriver National Institute of Child Health and Human De…
• GE Healthcare

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• Radboud University Nijmegen Medical Centre
• Leiden University Medical Center
• University of California
• Karolinska University Hospital-Solna
• Dana-Farber Cancer Institute

Clinical Trials | 212 trials

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• Diagnosis and Treatment of Pheochromocytoma

  conditions: Pheochromocytoma

  interventions: none

   

• Diagnosis of Pheochromocytoma

  conditions: Pheochromocytoma

  interventions: none

   

News | 8 stories

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• Cardiac Pheochromocytoma Presenting as Shortness of Breath

  American journal. - June 30, 2009

• [Articles] An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis

  Lancet. - July 29, 2009

Community

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• Shimon  Lecht

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