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Description: A hallucinogen formerly used as a veterinary anesthetic, and briefly as a general anesthetic for humans. Phencyclidine is similar to ketamine in structure and in many of its effects. Like ketamine, it can produce a dissociative state. It exerts its pharmacological action through inhibition of NMDA receptors (receptors, N-methyl-D-aspartate). As a drug of abuse, it is known as PCP and Angel Dust. [PubChem]
Drug Type: Small Molecule; Illicit; Experimental
Pharmacology: Phencyclidine works primarily as an NMDA receptor antagonist, which blocks the activity of the NMDA Receptor.
Mechanism of Action: The N-methyl-D-Aspartate (NMDA) receptor, a type of ionotropic receptor, is found on the dendrites of neurons and receives signals in the form of neurotransmitters. It is a major excitatory receptor in the brain. Normal physiological function requires that the activated receptor fluxes positive ions through the channel part of the receptor. PCP enters the ion channel from the outside of the neuron and binds, reversibly, to a site in the channel pore, blocking the flux of positive ions into the cell. PCP therefore inhibits depolarization of neurons and interferes with cognitive and other functions of the nervous system. [Wikipedia]
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Data Correlations | 40 studies

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Individual Studies

  • Drug-Induced Renal Tubular Toxicity

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    These data support the publication titled "A Gene Expression Signature that Predicts the Future Onset of Drug-Induced Renal Tubular Toxicity"

    Authors: Fielden MR, Eynon BP, Natsoulis G et al.

    Organization: Iconix Pharmaceuticals 325 E Middlefield…

  • Predicting Lung tumor-related carcinogenicity

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    Two-year rodent bioassays play a central role in evaluating both the carcinogenic potential of a chemical and generating quantitative information on the dose-response behavior for chemical risk assessments. The bioassays involved are expensive and time-consuming, requiring nearly lifetime exposures …

    Authors: Thomas RS, Pluta LJ, Page TJ et al.

    Organization: The Hamner Institutes for Health Science…
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Associated Researchers

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Thought leaders and organizations working on research involving phencyclidine.

View All Author iconAuthors
  • Yukihiro Noda
  • Athina Markou
  • Toshitaka Nabeshima
  • Michael K Harte
  • Svetlana Semenova
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Mylan Pharmaceuticals
  • Teva Pharmaceuticals USA
  • Abbott
  • Pfizer
  • PRAECIS Pharmaceuticals Inc.
View All Affiliations icon Organizations
  • University of Texas Medical Branch
  • Nagoya University Graduate School of Medicine
  • University of California
  • Queen's University
  • Yale University School of Medicine

Clinical Trials | 268 trials

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Community

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View All NextBio Users | 1 person
  • Galo Garcia Galo  Garcia

    Graduate Student

    UC Berkeley, Department of Molecular and Cell Biology

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