RESEARCH
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NEXTBIO COMMUNITY
Steroid or nuclear hormone receptors (4A nuclear receptor, NRs) constitute an important superfamily of transcription regulators that are involved in widely diverse physiological functions, including control of embryonic development, cell differentiation and homeostasis. Members of the superfamily include the steroid hormone receptors and receptors for thyroid hormone, retinoids, 1,25-dihydroxy-vitamin D3 and a variety of other ligands . The proteins function as dimeric molecules in nuclei to regulate the transcription of target genes in a ligand-responsive manner. In addition to C-terminal ligand-binding domains, these nuclear receptors contain a highly-conserved, N-terminal zinc-finger t...
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Compounds
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| Butyric Acid |
100
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| Spironolactone |
96
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| Benzethonium |
96
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| Bovinic Acid |
94
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| Mevastatin |
90
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| Ethylestrenol |
89
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 Individual Studies |
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Rattus norvegicus
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RNA Expression
Mus musculus
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Effect of the dual peroxisome proliferator-activated receptor-alpha/gamma agonist aleglitazar on risk of cardiovascular disease in patients with type 2 diabetes (SYNCHRONY): a phase II, randomised, dose-ranging study.
Authors: Robert R Henry, A Michael Lincoff, Sunder Mudaliar, Michael Rabbia, Cathy Chognot, Matthias Herz
Lancet 2009 Jul 11 -
Peroxisome proliferator-activated receptor-gamma-mediated effects in the vasculature.
Authors: Sheng Zhong Duan, Michael G Usher, Richard M Mortensen
Circulation research 2008 Feb 15
Thought leaders and organizations working on research involving peroxisome proliferator activated receptor gamma.
- Takeda Global Research & Development Center, Inc.
- PTC Therapeutics
- National Heart, Lung, and Blood Institute (NHLBI)
- The University of Hong Kong
- Aligarh Muslim University
- Harvard Medical School
- University of California, San Diego
- University of Tokyo
- University of California at San Diego and VA San Diego Healthcare Syst…
- University of Michigan Medical School
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The Effects of Peroxisome Proliferators Activated Receptor-Gamma (PPAR-γ) Agonists on Certain Biochemical and Inflammatory Markers in Metabolic Syndrome
conditions: Metabolic Syndrome
interventions: Pioglitazone ; Telmisartan
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Targeting Peroxisome Proliferator-Activated Receptor-Gamma in Peritoneal Dialysis Patients - Will it Reduce Inflammation, Atherosclerosis, Calcification and Improve Survival of Peritoneal Dialysis Patients?
conditions: Chronic Disease ; Kidney Diseases ; Cardiovascular Diseases
interventions: rosiglitazone
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Selective peroxisome proliferator-activated receptor {gamma} (PPAR{gamma}) modulation as a strategy for safer therapeutic PPAR{gamma} activation [Supplement: Therapeutic Advances for Insulin Resistance and Diabetes: Novel Pathways and the Development of Selective PPAR[gamma ] Modulators from Bench to Bedside]
American journal. - December 18, 2009 -
From bench to bedside: novel mechanisms and therapeutic advances through the development of selective peroxisome proliferator-activated receptor {gamma} modulators [Supplement: Therapeutic Advances for Insulin Resistance and Diabetes: Novel Pathways and the Development of Selective PPAR[gamma ] Modulators from Bench to Bedside]
American journal. - December 18, 2009
Community
Jennifer Hurst-Kennedy
Drug Delivery and Formulation Scientist
Sigmoid Pharma / UCD
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