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Description: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids. [PubChem]
Drug Type: Small Molecule; Experimental
Pharmacology: Palmitic acid is the first fatty acid produced during lipogenesis (fatty acid synthesis) and from which longer fatty acids can be produced. Palmitate negatively feeds back on acetyl-CoA carboxylase (ACC) which is responsible for converting acetyl-ACP to malonyl-ACP on the growing acyl chain, thus preventing further palmitate generation
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Data Correlations | 4 studies

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Genes category icon Genes
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613226 100 100
Clca3 96 96
Tpsab1 95 95
ASPM 94 94
C18orf24 92 92
CDH22 92 92
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Biogroups category icon Biogroups
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I31 - equistatin ({Actinia}) inhibi… 100 100
ACE Inhibitor Pathway 98 98
P53 Signaling Pathway 97 97
Growth factor, receptor 97 97
Glutathione Metabolism 97 97
EGF-like, type 3 96 96
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Individual Studies

  • C2C12 Myotubes in response to Palmitate

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    To identify mediators of obesity-linked reductions in PGC-1, we tested the effects of cellular nutrients in C2C12 myotubes.

    Authors: Crunkhorn S, Patti M

    Organization: Joslin Diabetes Center CMP Patti Lab 1 J…

  • Free fatty acids and TNF-alpha in hepg2/c3a cell culture

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    We developed a Three Stage Integrative Pathway Search (TIPS(c)) approach. The approach was tested on human liver cells to identify pathways that confer cytotoxicity.

    Authors: Li Zheng, Srivastava Shireesh, Chan Christina et al.

    Organization: Michigan State University Chemical Engin…
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Associated Researchers

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Thought leaders and organizations working on research involving palmitic acid.

View All Author iconAuthors
  • Michael Gaster
  • Arild C Rustan
  • Sarah E E Berry
  • Henning Beck-Nielsen
  • Christian A Drevon
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Enzymotec
  • University of Copenhagen
  • University of Texas Southwestern Medical Center
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDD…
  • Centre de Recherche en Nutrition Humaine Rhone-Alpe
View All Affiliations icon Organizations
  • King's College London
  • Odense University Hospital
  • University of Georgia
  • Institute of Theoretical and Experimental Biophysics RAS
  • University of Oslo

Clinical Trials | 10 trials

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Community

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View All NextBio Users | 2 people
  • No photo available Naresh  Kasoju

    Research Scholar

    Indian Institute of Technology - Guwahati

  • Scott Kerns Scott  Kerns

    Manager

    Children's Cancer & Blood Foundation Laboratories, Weill Cornell Medical College

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