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Description: Paliperidone is the primary active metabolite of the older antipsychotic risperidone. While its specific mechanism of action is unknown, it is believed paliperidone and risperidone act via similar, if not the same, pathways. It has been proposed that the drug's therapeutic activity in schizophrenia ismediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism. Paliperidone is also active as an antagonist at alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors, which may explain some of the other effects of the drug. Paliperidone was approved by the FDA for treatment of schizophrenia on December 20, 2006.
Drug Type: Small Molecule; Approved
Pharmacology: Paliperidone is an atypical antipsychotic developed by Janssen Pharmaceutica. Chemically, paliperidone is primary active metabolite of the older antipsychotic risperidone (paliperidone is 9-hydroxyrisperidone, i.e. risperidone with an extra hydroxyl group). While its specific mechanism of action is unknown, it is believed paliperidone and risperidone act via similar, if not the same, pathways.
Mechanism of Action: Paliperidone is the major active metabolite of risperidone. The mechanism of action of paliperidone, as with other drugs having efficacy in schizophrenia, is unknown, but it has been proposed that the drug's therapeutic activity in schizophrenia ismediated through a combination of central dopamine Type 2 (D2) and serotonin Type 2 (5HT2A) receptor antagonism.
Indication: For the treatment of schizophrenia.
Half Life: The terminal elimination half-life of paliperidone is approximately 23 hours.
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Thought leaders and organizations working on research involving paliperidone.

View All Author iconAuthors
  • Pilar Lim
  • Mariëlle Eerdekens
  • Michelle Kramer
  • Carla M Canuso
  • David Hough
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
  • Janssen Korea, Ltd., Korea
  • Indiana University School of Medicine
  • Yale University
  • Janssen Pharmaceutical K.K.
View All Affiliations icon Organizations
  • New York University School of Medicine
  • University of Alberta
  • Eastern State Hospital
  • University of Ulm
  • Albany Medical College

Clinical Trials | 103 trials

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