p53(TP53) - NextBio

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Search Term: p53 (gene: TP53)

Overview

tumor protein p53

This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that f...

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Data Correlations | 1,617 studies

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Normal tissues

Score

Mesenteric lymph nod…

100

Femur

B lymphoblast

Vulva

Caudate nucleus

Epidermis

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Compounds

Score

Octyl Phenol

100

Neocarzinostatin (ja…

Nsc 652287

Butyric Acid, Sodium…

8-isoprostaglandin E…

Sodium Tungstate(vi)

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Diseases

Score

Multiple malignancy

100

cancer of adrenal co…

Carcinoma in situ of…

Peutz-Jeghers syndro…

Glioma of spinal cor…

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Individual Studies
Cancer census - gene mutations in cancer and other diseases score: 100 \| Homo sapiens \| Mutations/Phenotypic The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al. Organization: Cancer Genome Project, Human Genome Anal…	OMIM - Neoplasms score: 100 \| Homo sapiens \| Mutations/Phenotypic This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories. Source: NextBio Library/Mutation and Phenotypic data

Individual Studies

Cancer census - gene mutations in cancer and other diseases

score: 100 | Homo sapiens | Mutations/Phenotypic

The Cancer Gene Census is an ongoing effort to catalogue those genes for which mutations have been causally implicated in cancer. The original census and analysis was published in Nature Reviews Cancer

Authors: P Andrew Futreal, Lachlan Coin, Mhairi Marshall et al.

Organization: Cancer Genome Project, Human Genome Anal…

OMIM - Neoplasms

score: 100 | Homo sapiens | Mutations/Phenotypic

This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories.

Source: NextBio Library/Mutation and Phenotypic data