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A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome.

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Data Correlations | 2,602 studies

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Tissues category icon Normal tissues
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B lymphoblast 100 100
Substantia nigra 96 96
Subthalamic nucleus 93 93
Trigeminal ganglion 92 92
Intestine 92 92
Mucosa of mouth 90 90
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Compounds category icon Compounds
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Allicin 100 100
Anisaldehyde 100 100
Thymol 93 93
Dictamnine 89 89
Perchloroethylene 74 74
Gentamicin C1 66 66
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Diseases category icon Diseases
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Effects of exposure … 100 100
Villous adenoma of c… 100 100
Starvation 83 83
Dengue shock syndrom… 74 74
Systemic inflammator… 72 72
Gastric cancer 71 71
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Individual Studies

  • Structure and Function of a Transcriptional Network Activated by Hog1

    score: 100100 | Saccharomyces cerevisiae Saccharomyces cerevisiae | RNA Expression   RNA Expression

    Cells regulate gene expression using a complex network of signaling pathways, transcription factors and promoters. We analyzed gene expression in single and multiple mutant strains to build a quantitative model of the Hog1 MAPK-dependent osmotic stress response in budding yeast.

    Authors: Capaldi P Andrew, Kaplan Tommy, Liu Ying et al.

    Organization: Harvard University MCB O'Shea Lab Bauer …
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Associated Researchers

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Thought leaders and organizations working on research involving nucleolus.

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  • Ingrid Grummt
  • Matthias Mann
  • Peter J Shaw
  • Rosa Bernardi
  • Daniele Guardavaccaro
View All Affiliations icon Organizations
  • German Cancer Research Center
  • Washington University
  • Howard Hughes Medical Institute
  • John Innes Centre
  • New York University School of Medicine

Community

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