A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

Data Correlations | 15 studies

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Genes	Score
HNF1B	100
PPARG	100
AKT2	100
CYB5R4	100
HMGA1	100
HNF1A	100

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Biogroups	Score
Antigen Processing and Presentation	100
Hematopoietic Cell Lineage	99
CTL Mediated Immune Response Agains…	98
Calcineurin Nf At Signaling	97
Ribosome	97
Neuropeptides VIP and PACAP Inhibit…	97

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Individual Studies
Effects of laughter in patients with type 2 diabetes Homo sapiens |   RNA Expression Peripheral blood from patients with type II diabetes before and after watching a comic video or spending tedious time. Organization: Hitachi, Ltd. Life Science Group Biotech…	Laughter regulates blood glucose levels and gene expression Homo sapiens |   RNA Expression Gene expression analysis were obtained before the meal and 1.5 hours after the event of listening to a Japanese comic or a monotonous academic lecture without humor. Organization: Hitachi, Ltd. Life Science Group Biotech…

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Literature | 10,369 results

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• Downregulation of diacylglycerol kinase delta contributes to hyperglycemia-induced insulin resistance.

  Authors: Alexander V Chibalin, Ying Leng, Elaine Vieira, Anna Krook, Marie Björnholm, Yun Chau Long, Olga Kotova, Zhihui Zhong, Fumio Sakane, Tatiana Steiler,…

  Cell 2008 Feb 8

• Efficacy and safety of atorvastatin in the prevention of cardiovascular end points in subjects with type 2 diabetes: the Atorvastatin Study for Prevention of Coronary Heart Disease Endpoints in non-insulin-dependent diabetes mellitus (ASPEN).

  Authors: Robert H Knopp, Michael d'Emden, Johan G Smilde, Stuart J Pocock

  Diabetes care 2006 Jul

Associated Researchers

Thought leaders and organizations working on research involving non-insulin-dependent diabetes mellitus.

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• V L Magnuson
• P Chines
• E R Hauser
• D Guelfi
• K L Mohlke

View All Clinical Trials Sponsors

• National Heart, Lung, and Blood Institute (NHLBI)
• Takeda Global Research & Development Center, Inc.
• Pfizer
• National Center for Complementary and Alternative Medicine (NCCAM)
• Washington University School of Medicine

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• University of Brescia
• Kadir Has University
• Karolinska Institutet
• Harborview Medical Center
• Cleveland Clinic Foundation

Clinical Trials | 99 trials

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• Mapping Genes for Non-Insulin Dependent Diabetes Mellitus

  conditions: Non-Insulin Dependent Diabetes Mellitus

  interventions: none

   

• Atorvastatin and LDL Profile in Non-Insulin Dependent Diabetes Mellitus

  conditions: Hyperlipidemia ; Diabetes Mellitus, Type 2 ; Non-Insulin Dependent Diabetes Mellitus

  interventions: Atorvastatin ; Placebo

   

News | 2 stories

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• EDITORIAL: Islet and Pancreatic Transplantation — Autoimmunity and Alloimmunity

  NEJM.

• Depression and Clinical Outcomes in Heart Failure: An OPTIMIZE-HF Analysis

  American journal. - March 31, 2009

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