A disorder affecting the cranial nerves or the peripheral nervous system. It is manifested with pain, tingling, numbness, and muscle weakness. It may be the result of physical injury, toxic substances, viral diseases, diabetes, renal failure, cancer, and drugs. -- 2004

Data Correlations | 37 studies

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Genes	Score
PMP22	100
KIF1B	100
LMNA	100
MPZ	100
RET	100
OPA1	100

View Top Genes

Biogroups	Score
Predicted Gene Targets for miR-145	100
P53 Signaling Pathway	99
MAPK Signaling Pathway	99
Predicted Gene Targets for miR-381	98
Predicted Gene Targets for miR-200b	97
Predicted Gene Targets for miR-148	97

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Individual Studies

Peripheral neuropathies from PMP22 mutants Mus musculus |   RNA Expression We compared gene expression at ages P4 and P60 in sciatic nerve of wild type mice and mice with peripheral neuropathies caused by altered Pmp22 gene dosage (homozygous knockout or transgene) or a point mutation (Trembler). Authors: Giambonini-Brugnoli G, Buchstaller J, Sommer L et al. Organization: Swiss Federal Institute of Technology In…

Normal and glaucomatous astrocytes Homo sapiens |   RNA Expression Astrocytes from optic nerve head from donors with and without glaucoma Authors: Hernandes MR, Agapova OA, Yang P Organization: Northwestern University Ophthalmology He…

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Literature | 40,868 results

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• Mutations in FAM134B, encoding a newly identified Golgi protein, cause severe sensory and autonomic neuropathy.

  Authors: Ingo Kurth, Torsten Pamminger, J Christopher Hennings, Désirée Soehendra, Antje K Huebner, Annelies Rotthier, Jonathan Baets, Jan Senderek, Haluk Topaloglu, Sandra A Farrell,…

  Nature genetics 2009 Nov

• Disrupted function and axonal distribution of mutant tyrosyl-tRNA synthetase in dominant intermediate Charcot-Marie-Tooth neuropathy.

  Authors: Albena Jordanova, Joy Irobi, Florian P Thomas, Patrick Van Dijck, Kris Meerschaert, Maarten Dewil, Ines Dierick, An Jacobs, Els De Vriendt, Velina Guergueltcheva,…

  Nature genetics 2006 Feb

Associated Researchers

Thought leaders and organizations working on research involving neuropathy.

View All Authors

• Vincent Timmerman
• Peter De Jonghe
• Joy Irobi
• Eva L Feldman
• Ines Dierick

View All Clinical Trials Sponsors

• UCB
• Pfizer
• Eli Lilly and Company
• Florida Atlantic University
• National Center for Complementary and Alternative Medicine (NCCAM)

View All Organizations

• University of Michigan
• University of Calgary
• University of Antwerp
• University Medical Center Hamburg-Eppendorf
• Baylor College of Medicine

Clinical Trials | 3,749 trials

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• Effects of Pulsatile Insulin Delivery on Diabetic Neuropathy in Patients With Types 1 and 2 Diabetes Mellitus

  conditions: Diabetes Mellitus, With Complications

  interventions: Effect of Pulsatile IV insulin on diabetic neuropathy ; Effect of Pulsatile IV Insulin on diabetic neuropathy

   

• A Study of Rituxan in the Treatment of Polyneuropathies Associated With Serum IgM Autoantibodies

  conditions: Peripheral Neuropathy

  interventions: Rituxan

   

News | 60 stories

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• What Is Neuropathy? What Causes Neuropathy?

  Medical News Today. - April 29, 2009

• Health Matters : What is Diabetic Neuropathy ?

  PR-inside.com. - November 03, 2009

Community

View All NextBio Users | 3 people

• Metin  Yavuz

  Researcher

  Ohio College of Podiatric Medicine

• Peter  Ianakiev

  Scientist

  University of Connecticut Health Ctr

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