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Description: An anti-inflammatory agent with analgesic and antipyretic properties. Both the acid and its sodium salt are used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea, and acute gout. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Naproxen is a member of the arylacetic acid group of nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen has analgesic and antipyretic properties. As with other NSAIDs, its mode of action is not fully understood; however, its ability to inhibit prostaglandin synthesis may be involved in the anti-inflammatory effect.
Mechanism of Action: The mechanism of action of naproxen, like that of other NSAIDs, is believed to be associated with the inhibition of cyclooxygenase activity. Two unique cyclooxygenases have been described in mammals. The constitutive cyclooxygenase, COX-1, synthesizes prostaglandins necessary for normal gastrointestinal and renal function. The inducible cyclooxygenase, COX-2, generates prostaglandins involved in inflammation. Inhibition of COX-1 is thought to be associated with gastrointestinal and renal toxicity while inhibition of COX-2 provides anti-inflammatory activity.
Indication: For the treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, tendinitis, bursitis, and acute gout. Also for the relief of mild to moderate pain and the treatment of primary dysmenorrhea.
Half Life: The observed terminal elimination half-life is approximately 15 hours.
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Data Correlations | 8 studies

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Genes category icon Genes
Score Help
PTGS2 100 100
PTGS1 100 100
Mbl1 100 100
TARBP2 92 92
DUSP11 89 89
FAIM2 84 84
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Biogroups category icon Biogroups
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Arachidonic Acid Metabolism 100 100
Prostaglandin Synthesis Regulation 100 100
SNARE Interactions In Vesicular Tra… 98 98
Neuroactive Ligand Receptor Interac… 98 98
Adipocytokine Signaling Pathway 98 98
NF-kB Signaling Pathway 98 98
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Individual Studies

  • β-adrenergic agonist isoproterenol-induced tachycardia and myocardial necrosis

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    Gene expression was evaluated in the myocardium of male Wistar rats after a single sc administration of 0.5 mg of isoproterenol, a β-adrenergic agonist that causes acute tachycardia with subsequent myocardial necrosis.

    Authors: Mikaelian I, Kanwal C

    Organization: Hoffman-La Roche RIGG 340 Kingsland Stre…

  • RAW 264.7 cells treated with LPS, ISO, PGE2, LPS+ISO and LPS+PGE2

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    Characterization of modulation of TLR ligands by non-TLR ligands using murine RAW 264.7 cells by treating with with LPS, IFN-gamma, 2-methyl-thio-ATP (2MA), PGE(2), and isoproterenol (ISO).

    Authors: Zhu Xiaocui, Chang MiSook, Hsueh Robert et al.

    Organization: California Institute of Technology Biolo…
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Associated Researchers

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Thought leaders and organizations working on research involving naproxen.

View All Author iconAuthors
  • Paola Patrignani
  • Marc C Hochberg
  • Alex Fragoso
  • Gabriele Merciaro
  • Patrizia Di Gregorio
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Pfizer
  • Pozen
  • Bayer
  • AstraZeneca
  • Primus Pharmaceuticals
View All Affiliations icon Organizations
  • G. d'Annunzio University
  • University of Matanzas
  • Mahidol University
  • Radboud University Nijmegen Medical Centre
  • New York University School of Medicine

Clinical Trials | 235 trials

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