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A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associ...

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Data Correlations | 9 studies

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Genes category icon Genes
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CCL2 100 100
IFNG 100 100
SLC11A1 100 100
IFNGR1 100 100
CD209 100 100
SP110 100 100
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Biogroups category icon Biogroups
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Cytokine Cytokine Receptor Interact… 100 100
Cytokine Network 99 99
Selective Expression of Chemokine R… 98 98
Small chemokine, interleukin-8-like 97 97
Dendritic Cells (DC) In Regulating … 97 97
Toll-like Receptor Signaling Pathwa… 96 96
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Individual Studies

  • DCs stimulated with Mycobacterium tuberculosis

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    The inhibitory axis of PD-1 expressed on T cells and its ligands produced by APCs mediates T cell exhaustion in chronic viral infection. We asked whether temporality of the infectious process is decisive for regulation through PD-1/PD-Ligand and investigated its impact on chronic bacterial infection…

    Authors: Winau F, Hegasy G, Kaufmann SH et al.

    Organization: Max-Planck-Institute for Infection Biolo…

  • M. tuberculosis sigma factor E effects in human THP1 cells

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    omparison of responses to infections Mycobacterium tuberculosis (Mtb) is well adapted to survive in macrophages and usually subverts the bactericidal mechanisms of these professional phagocytes.

    Authors: Fontan Patricia, Aris M Virginie, Ghanny S Saleena et al.

    Organization: PHRI-UMNDJ Center For Applied Genomics S…
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Associated Researchers

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Thought leaders and organizations working on research involving mycobacterium tuberculosis infection.

View All Author iconAuthors
  • Ajit Lalvani
  • JoAnne L Flynn
  • Katie Ewer
  • Michael S Glickman
  • Andrea M Cooper
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • National Heart, Lung, and Blood Institute (NHLBI)
  • GlaxoSmithKline
  • University of Oxford
  • University Hospital, Geneva
View All Affiliations icon Organizations
  • University of Pittsburgh School of Medicine
  • University of Medicine and Dentistry of New Jersey
  • University of Oxford
  • Trudeau Institute
  • Research Center Borstel

Clinical Trials | 174 trials

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