Derangement in size and number of muscle fibers occurring with aging, reduction in blood supply, or following immobilization, prolonged weightlessness, malnutrition, and particularly in denervation.

Data Correlations | 15 studies

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Genes	Score
PMP22	100
KIF1B	100
MPZ	100
LMNA	100
NAPB	100
SEPT9	100

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Biogroups	Score
Actions of Nitric Oxide in the Hear…	100
Glycolysis and Gluconeogenesis	98
Blockade of Neurotransmitter Relase…	98
The Role of FYVE-finger Proteins In…	98
Calcineurin Pathway	98
GPCR Pathway	98

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Individual Studies

48h Knee Immobilization in human Homo sapiens |   RNA Expression Our results suggest that 48h of immobilization increases expression of mRNA for components of the UPP and MT function while decreasing mRNA and protein for components involved in ECM integrity. We hypothesized that 48h of immobilization would increase gene expression and respective protein products … Authors: Clarkson Priscilla Organization: Children's National Medical Center Child…

Skeletal muscle atrophy and Runx1 dysregulation Mus musculus |   RNA Expression In skeletal muscle, the pattern of electrical activity regulates the expression of proteins involved in synaptic transmission, contraction and metabolism. Disruptions in electrical activity, resulting from prolonged bed-rest, cast-immobilization or trauma, inevitably lead to muscle atrophy. The mech… Authors: Burden SJ Organization: NIH Neuroscience Microarray Consortium N…

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Literature | 4,135 results

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• Role of beta-adrenoceptor signaling in skeletal muscle: implications for muscle wasting and disease.

  Authors: Gordon S Lynch, James G Ryall

  Physiological reviews 2008 Apr

• IKKbeta/NF-kappaB activation causes severe muscle wasting in mice.

  Authors: Dongsheng Cai, J Daniel Frantz, Nicholas E Tawa, Peter A Melendez, Byung-Chul Oh, Hart G W Lidov, Per-Olof Hasselgren, Walter R Frontera, Jongsoon Lee, David J Glass,…

  Cell 2004 Oct 15

Associated Researchers

Thought leaders and organizations working on research involving muscle wasting.

View All Authors

• Francisco J López-Soriano
• Sílvia Busquets
• James G Ryall
• Josep M Argilés
• Gordon S Lynch

View All Clinical Trials Sponsors

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDD…
• National Institute of Arthritis and Musculoskeletal and Skin Diseases …
• National Institute of Allergy and Infectious Diseases (NIAID)
• National Center for Research Resources (NCRR)
• University of Rochester

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• University of Melbourne
• Universitat de Barcelona
• Radboud University Nijmegen Medical Centre
• University of Cincinnati
• Beth Israel Deaconess Medical Center

Clinical Trials | 75 trials

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• Study of GTx-024 on Muscle Wasting (Cachexia) Cancer.

  conditions: Cachexia

  interventions: GTx-024 ; GTx-024 ; Placebo

   

• Study of the Effect of GTx-024 on Muscle Wasting in Patients With Cancer

  conditions: Non-Small Cell Lung Cancer

  interventions: GTx-024 ; GTx-024 ; placebo

   

News | 10 stories

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• New clues about the basis of muscle wasting disease

  Science Daily. - March 14, 2010

• Muscle Atrophy Through Thick But Not Thin

  Medical News Today. - June 09, 2009

Community

View All NextBio Users | 2 people

• Thierry  Touvier

  Ph.D.

  Ospedale San Raffaele

• Burcin  Ikiz

  Graduate Student

  Columbia University

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