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Description: An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of clozapine. (From AMA Drug Evaluations Annual, 1994, p283)
Drug Type: Small Molecule; Approved
Pharmacology: Molindone is a dihydroindolone compound which is not structurally related to the phenothiazines, the butyrophenones or the thioxanthenes. Molindone has a pharmacological profile in laboratory animals which predominantly resembles that of major tranquilizers causing reduction of spontaneous locomotion and aggressiveness, suppression of a conditioned response and antagonism of the bizarre stereotyped behavior and hyperactivity induced by amphetamines. In addition, molindone antagonizes the depression caused by the tranquilizing agent tetrabenazine.
Mechanism of Action: The exact mechanism has not been established, however, based on electroencephalogram (EEG) studies, molindone is thought to act by occupying dopamine (D2) receptor sites in the reticular activating and limbic systems in the brain, thus decreasing dopamine activity.
Indication: For the management of the manifestations of psychotic disorders.
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Data Correlations | 1 study

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Genes category icon Genes
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CD86 100 100
TBL1X 98 98
MAP4 94 94
PIN4 94 94
51136 93 93
AZIN1 88 88
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Biogroups category icon Biogroups
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Protein Export 100 100
Claudin 99 99
Zinc finger, CCCH-type 99 99
PMP-22/EMP/MP20/Claudin 98 98
DNA/RNA helicase, ATP-dependent, DE… 97 97
Phox-like 97 97
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Individual Studies

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving molindone.

View All Author iconAuthors
  • Robert L Findling
  • Linmarie Sikich
  • J Kleijnen
  • Jon McClellan
  • R Lewis
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • State University of New York - Upstate Medical University
  • National Institute of Mental Health (NIMH)
  • National Institute of Allergy and Infectious Diseases (NIAID)
View All Affiliations icon Organizations
  • University of Pittsburgh School of Medicine
  • University of Washington
  • Leeds Metropolitan University
  • Covance Laboratories Inc
  • University of North Carolina at Chapel Hill

Clinical Trials | 20 trials

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