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Description: An anthracenedione-derived antineoplastic agent. [PubChem]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Mitoxantrone has been shown in vitro to inhibit B cell, T cell, and macrophage proliferation and impair antigen presentation, as well as the secretion of interferon gamma, TNFa, and IL-2.
Mechanism of Action: Mitoxantrone, a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA) through hydrogen bonding, causes crosslinks and strand breaks. Mitoxantrone also interferes with ribonucleic acid (RNA) and is a potent inhibitor of topoisomerase II, an enzyme responsible for uncoiling and repairing damaged DNA. It has a cytocidal effect on both proliferating and nonproliferating cultured human cells, suggesting lack of cell cycle phase specificity.
Indication: For the treatment of secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis
Half Life: 75 hours
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Data Correlations | 2 studies

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Genes category icon Genes
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TOP2A 100 100
SLC38A2 98 98
TRIB1 98 98
ZBED5 94 94
C1orf63 92 92
IER5 89 89
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Biogroups category icon Biogroups
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Zinc finger, C2H2-subtype 100 100
Krueppel-associated box 100 100
MHC class I, alpha chain, C-termina… 99 99
Transcriptional regulator SCAN 99 99
I21 - secretogranin V 99 99
Tudor 98 98
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Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving mitoxantrone.

View All Author iconAuthors
  • Hans-Peter Hartung
  • Carolyn A Felix
  • Christine P Donahue
  • James H Hurley
  • Edward J Fox
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • M.D. Anderson Cancer Center
  • Sidney Kimmel Comprehensive Cancer Center
  • UCSF Helen Diller Family Comprehensive Cancer Center
  • OHSU Knight Cancer Institute
  • Wyeth
View All Affiliations icon Organizations
  • Heinrich Heine University
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • Northwestern University
  • University of Colorado at Denver
  • University of Washington

Clinical Trials | 378 trials

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