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Description: A tetracycline analog, having a 7-dimethylamino and lacking the 5 methyl and hydroxyl groups, which is effective against tetracycline-resistant staphylococcus infections. [PubChem]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Minocycline, the most lipid soluble and most active tetracycline antibiotic, is, like doxycycline, a long-acting tetracycline. Minocycline's effects are related to the inhibition of protein synthesis. Although minocycline's broader spectrum of activity, compared to other members of the group, includes activity against Neisseria meningitidis, its use as a prophylaxis is no longer recomended because of side effects (dizziness and vertigo). Current research is examining the possible neuroprotective effects of minocycline against progression of Huntington's Disease, an inherited neurodegenerative disorder. The neuroprotective action of minocycline may include its inhibitory effect on 5-lipoxygenase, an inflammatory enzyme associated with brain aging.
Mechanism of Action: Minocycline passes directly through the lipid bilayer or passively diffuses through porin channels in the bacterial membrane. Tetracyclines like minocycline bind to the 30S ribosomal subunit, preventing the binding of tRNA to the mRNA-ribosome complex and interfering with protein synthesis.
Indication: For the treatment of infections caused by susceptible strains of microorganisms, such as Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsial pox and tick fevers caused by Rickettsiae, upper respiratory tract infections caused by Streptococcus pneumoniae and for the treatment of asymptomatic carriers of Neisseria meningitidis.
Half Life: 11-22 hours
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Data Correlations | 1 study

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Genes category icon Genes
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CHAC1 100 100
S100A8 99 99
CTH 97 97
STC2 95 95
AKAP10 92 92
TRIB3 92 92
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RNA-directed DNA polymerase (revers… 100 100
Reelin Signaling Pathway 95 95
Histone core 94 94
Cysteine Metabolism 93 93
Rossmann-like alpha/beta/alpha sand… 92 92
Ras-association 92 92
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Individual Studies

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving minocycline.

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  • Anirban Basu
  • Manoj Kumar Mishra
  • Gerald Wolf
  • Paul Desjardins
  • Ann-Charlotte Granholm
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Taiwan University Hospital
  • State University of New York - Downstate Medical Center
  • Ranbaxy Laboratories Limited
  • National Institute of Neurological Disorders and Stroke (NINDS)
  • Johnson & Johnson Consumer & Personal Products Worldwide
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  • University of California
  • National Brain Research Centre
  • University of Montreal
  • Otto-von-Guericke University Magdeburg
  • University of Utah

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