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Description: A central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine. [PubChem]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Methylphenidate is a central nervous system stimulant used most commonly in the treatment of attention-deficit disorders in children and for narcolepsy. Its mechanisms appear to be similar to those of dextroamphetamine.
Mechanism of Action: Methylphenidate blocks dopamine uptake in central adrenergic neurons by blocking dopamine transport or carrier proteins. Methylphenidate acts at the brain stem arousal system and the cerebral cortex and causes increased sympathomimetic activity in the central nervous system. Alteration of serotonergic pathways via changes in dopamine transport may result.
Indication: For use as an integral part of a total treatment program which typically includes other remedial measures (psychological, educational, social) for a stabilizing effect in children with a behavioral syndrome characterized by the following group of developmentally inappropriate symptoms: moderate-to-severe distractibility, short attention span, hyperactivity, emotional lability, and impulsivity.
Half Life: 2.4 hours in children and 2.1 hours in adults
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SLC6A3 100 100
SLC6A2 95 95
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    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Thought leaders and organizations working on research involving methylphenidate.

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  • S J Wanchoo
  • L Eugene Arnold
  • Amy K Wagner
  • Amina S Khan
  • A C Swann
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute on Drug Abuse (NIDA)
  • Massachusetts General Hospital
  • M.D. Anderson Cancer Center
  • Medice Arzneimittel Pütter GmbH & Co KG
  • National Institute of Mental Health (NIMH)
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  • Rosalind Franklin University of Medicine and Science
  • University Hospital Basel
  • University of Texas Medical School at Houston
  • University of California
  • Harvard Medical School

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