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Description: An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)
Drug Type: Small Molecule; Approved
Pharmacology: Methoxyflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Mechanism of Action: Methoxyflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Methoxyflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Methoxyflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Indication: For use in the induction and maintenance of general anesthesia
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Data Correlations | 3 studies

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Genes category icon Genes
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MT-ND1 100 100
GABRA1 87 87
GLRA1 86 86
GRIA1 85 85
KCNA1 84 84
ATP5D 83 83
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Biogroups category icon Biogroups
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Cardiac Protection Against Ros 100 100
Neurotransmitter-gated ion-channel … 98 98
Gamma-Aminobutyric Acid Receptor Li… 97 97
Neurotransmitter-gated ion-channel … 97 97
Neurotransmitter-gated ion-channel 97 97
Neuroactive Ligand Receptor Interac… 93 93
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Individual Studies

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    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…
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Associated Researchers

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Thought leaders and organizations working on research involving methoxyflurane.

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  • Omar M Yaghi
  • Michael O'Keeffe
  • Stephen Bernard
  • Mohamed Eddaoudi
  • Banglin Chen
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  • Medical Developments International Limited
  • German Parkinson Study Group (GPS)
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  • University of Michigan
  • Washington University
  • European Molecular Biology Laboratory
  • Stanford University School of Medicine
  • University of Oslo

Clinical Trials | 2 trials

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