Chronic glomerulonephritis characterized histologically by proliferation of MESANGIAL CELLS, increase in the MESANGIAL EXTRACELLULAR MATRIX, and a thickening of the glomerular capillary walls. This may appear as a primary disorder or secondary to other diseases including infections and autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Various subtypes are classified by their abnormal ultrastructures and immune deposits. Hypocomplementemia is a characteristic feature of all types of MPGN.

Data Correlations | 2 studies

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Genes	Score
ABCA1	100
CFH	96

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Biogroups	Score
ABC Transporters General	100
ABC transporter-like	100
Statin Pathway	99
AAA+ ATPase, core	98
Sushi/SCR/CCP	98
Complement control module	97

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Individual Studies

OMIM - Kidney diseases Homo sapiens |   Mutations/Phenotypic This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories. Source: NextBio Library/Mutation and Phenotypic data

Mouse Phenotypes - Kidney diseases Mus musculus |   Mutations/Phenotypic This study contains curated mouse gene mutation data extracted from the Mouse Genome Database (MGD) at The Jackson Laboratory, Bar Harbor, Maine. Additional computational processing and curation of mouse phenotype data was performed to further organize and group data from related phenotypes into uni… Source: NextBio Library/Mutation and Phenotypic data

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Literature | 2,852 results

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• Oligosaccharide composition is similar in drusen and dense deposits in membranoproliferative glomerulonephritis type II.

  Authors: Yvonne B D'souza, Carolyn J P Jones, Colin D Short, Ian S D Roberts, Richard E Bonshek

  Kidney international 2009 Apr

• Hereditary and acquired complement dysregulation in membranoproliferative glomerulonephritis.

  Authors: Christoph Licht, Veronique Fremeaux-Bacchi

  Thrombosis and haemostasis 2009 Feb

Associated Researchers

Thought leaders and organizations working on research involving membranoproliferative glomerulonephritis.

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• Charles E Alpers
• Christoph Licht
• Peter F Zipfel
• Pilar Sánchez-Corral
• Kikuo Iitaka

View All Clinical Trials Sponsors

• Mayo Clinic
• University of Iowa
• National Institute of Arthritis and Musculoskeletal and Skin Diseases …
• Kenta Biotech Ltd
• ClinTrio Ltd.

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• University of Washington
• Manchester Royal Eye Hospital
• Hospital for Sick Children
• University of Erlangen-Nürnberg
• Imperial College

Clinical Trials | 8 trials

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• Pilot Study of Rituximab for Membranoproliferative Glomerulonephritis

  conditions: Membranoproliferative Glomerulnephritis

  interventions: Rituximab

   

• Sulodexide Treatment in Patients With Dense Deposit Disease

  conditions: Dense Deposit Disease

  interventions: Sulodexide

   

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