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Description: A non-steroidal anti-inflammatory agent with antipyretic and antigranulation activities. It also inhibits prostaglandin biosynthesis. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Meclofenamic acid is a nonsteroidal agent which has demonstrated anti-inflammatory, analgesic, and antipyretic activity in laboratory animals.
Mechanism of Action: The mode of action, like that of other nonsteroidal anti-inflammatory agents, is not known. Therapeutic action does not result from pituitary-adrenal stimulation. In animal studies, meclofenamic acid was found to inhibit prostaglandin synthesis and to compete for binding at the prostaglandin receptor site. In vitro meclofenamic acid was found to be an inhibitor of human leukocyte 5-lipoxygenase activity. These properties may be responsible for the anti-inflammatory action of meclofenamic acid. There is no evidence that meclofenamic acid alters the course of the underlying disease.
Indication: For the relief of mild to moderate pain, for the treatment of primary dysmenorrhea and for the treatment of idiopathic heavy menstrual blood loss. Also for relief of the signs and symptoms of acute and chronic rheumatoid arthritis and osteoarthritis.
Half Life: In a study in 10 healthy subjects following a single oral dose the apparent elimination half-life ranged from 0.8 to 5.3 hours. Metabolite I (3-hydroxymethyl metabolite of meclofenamic acid) has a mean half-life of approximately 15 hours.
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Data Correlations | 2 studies

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Genes category icon Genes
Score Help
NMD3 100 100
440354 94 94
MET 91 91
STK25 90 90
SOLH 86 86
LPIN1 85 85
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Biogroups category icon Biogroups
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Biotin Metabolism 100 100
TALL1 Pathway 99 99
WNT Ca2 Cyclic GMP Pathway 97 97
Phosphorylation of MEK1 by CDK5/P35… 95 95
Nucleosome assembly protein (NAP) 94 94
Butyrophylin-like 94 94
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Individual Studies

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    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Broad Connectivity Map (CMAP 2.0) compound database

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    A reference collection of genome-wide transcriptional expression data from cultured human cells treated with bioactive small molecules that enable the discovery of functional connections between drugs, genes and diseases through the transitory feature of common gene-expression changes.

    Authors: Lamb J

    Organization: Broad Institute Seven Cambridge Center C…
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Associated Researchers

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Thought leaders and organizations working on research involving meclofenamic acid.

View All Author iconAuthors
  • John L Zhou
  • Shwu-Jiuan Sheu
  • D Robert E Abayasekara
  • Mie Hirohata
  • Q Wang
View All Affiliations icon Organizations
  • University of Sussex
  • Kanazawa University Graduate School of Medical Science
  • University of London
  • Royal Free and University College Medical School
  • Vanderbilt University School of Medicine

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