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Description: A benzodiazepine used as an anti-anxiety agent with few side effects. It also has hypnotic, anticonvulsant, and considerable sedative properties and has been proposed as a preanesthetic agent. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Lorazepam, a benzodiazepine not transformed to active metabolites, is used to treat anxiety, status epilepticus, and for sedation induction and anterograde amnesia.
Mechanism of Action: Lorazepam binds to central benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
Indication: For the management of anxiety disorders or for the short-term relief of the symptoms of anxiety or anxiety associated with depressive symptoms
Half Life: 12 hours
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Data Correlations | 4 studies

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Genes category icon Genes
Score Help
TSPO 100 100
TAC3 100 100
ALB 91 91
CIT 91 91
Spt1 90 90
AQP2 89 89
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Biogroups category icon Biogroups
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Multi-Drug Resistance Factors (MRP … 100 100
Cardiac Protection Against Ros 100 100
Proteasome 100 100
B Lymphocyte Cell Surface Molecules 99 99
Linoleic Acid Metabolism 99 99
EGF, extracellular 99 99
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Individual Studies

  • Drug target sets for approved compounds

    Homo sapiens Homo sapiens | Therapeutic   Therapeutic

    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Murine liver after treatment for 2 weeks with various carcinogens and non-carcinogens

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    In this study we used oligonucleotide microarray analysis to identify genes that were up- or downregulated in mouse liver early after treatment with different known carcinogens, including oxazepam, o-nitrotoluene and methyleugenol, or the non-carcinogens p-nitrotoluene, eugenol and acetaminophen.

    Source: NextBio Library/Pharmacology and Toxicology
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Associated Researchers

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Thought leaders and organizations working on research involving lorazepam.

View All Author iconAuthors
  • John J Sidtis
  • Anne Giersch
  • Nunzio Pomara
  • David J Greenblatt
  • John P Kress
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute on Alcohol Abuse and Alcoholism (NIAAA)
  • AstraZeneca
  • Eunice Kennedy Shriver National Institute of Child Health and Human De…
  • GlaxoSmithKline
  • University of Malawi College of Medicine
View All Affiliations icon Organizations
  • Hôpitaux Universitaires de Strasbourg
  • Universite Blaise Pascal
  • Centre Hospitalier Régional Universitaire de Strasbourg
  • University of Malawi
  • University of California

Clinical Trials | 166 trials

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News | 7 stories

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