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A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver invol...

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Data Correlations | 26 studies

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Genes category icon Genes
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FOXM1 100 100
CDKN1A 100 100
TXNIP 100 100
APC 100 100
NFE2L1 100 100
CTNNB1 100 100
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Biogroups category icon Biogroups
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Cytochrome P450 Protein Family 100 100
Cytochrome P450, E-class, group I 100 100
Metabolism of Xenobiotics by Cytoch… 100 100
Gamma Hexachlorocyclohexane Degrada… 99 99
Fatty Acid Metabolism 99 99
Bile Acid Biosynthesis 98 98
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Individual Studies

  • Hepatocellular Carcinoma Grade and Iron Homeostasis

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    To improve the clinical management of human hepatocellular carcinoma (HCC) by accurate identification, at diagnosis, of patients at risk of recurrence after primary treatment for HCC

    Authors: Suk Mei Wang, London Lucien P J Ooi, Kam M Hui

    Organization: Bek Chai Heah Laboratory of Cancer Genom…

  • Genome wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    Gene expression profiles of 75 tissue samples were analyzed representing the stepwise carcinogenic process from pre-neoplastic lesions (cirrhosis and dysplasia) to HCC, including four neoplastic stages (very early HCC to metastatic tumors) from patients with HCV infection. Gene signatures that accur…

    Authors: Wurmbach E, Chen Y, Khitrov G et al.

    Organization: Mount Sinai School of Medicine Hematolog…
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Associated Researchers

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Thought leaders and organizations working on research involving liver carcinoma.

View All Author iconAuthors
  • Josep M Llovet
  • Augusto Villanueva
  • Jordi Bruix
  • Hashem B El-Serag
  • Chien-Jen Chen
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Eastern Hepatobiliary Surgery Hospital
  • National Taiwan University Hospital
  • ImClone LLC
  • Fudan University
  • Tularik
View All Affiliations icon Organizations
  • National Cancer Institute
  • University of Barcelona
  • Cold Spring Harbor Laboratory
  • University of Minnesota
  • Mount Sinai School of Medicine

Clinical Trials | 3,421 trials

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Community

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