White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterised by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation.

Data Correlations | 2 studies

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Genes	Score
MLC1	100
DARS2	100
EIF2B5	100
EIF2B1	100
EIF2B3	100
EIF2B4	99

View Top Genes

Biogroups	Score
VEGF, Hypoxia, and Angiogenesis	100
Regulation of EIF2	96
IGF-1 mTOR Pathway	94
Mitochondrial Fatty Acid Betaoxidat…	94

View Top Biogroups

Individual Studies
OMIM - Disease of brain Homo sapiens |   Mutations/Phenotypic This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories. Source: NextBio Library/Mutation and Phenotypic data	OMIM - Vascular disease Homo sapiens |   Mutations/Phenotypic This study contains curated human phenotype data extracted from OMIM. Additional computational processing and curation of the phenotype data was performed to further organize and group data from related phenotypes into unifying disease categories. Source: NextBio Library/Mutation and Phenotypic data

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Literature | 6,099 results

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• RNASET2-deficient cystic leukoencephalopathy resembles congenital cytomegalovirus brain infection.

  Authors: Marco Henneke, Simone Diekmann, Andreas Ohlenbusch, Jens Kaiser, Volkher Engelbrecht, Alfried Kohlschütter, Ralph Krätzner, Marcos Madruga-Garrido, Michèle Mayer, Lennart Opitz,…

  Nature genetics 2009 Jul

• Mitochondrial aspartyl-tRNA synthetase deficiency causes leukoencephalopathy with brain stem and spinal cord involvement and lactate elevation.

  Authors: Gert C Scheper, Thom van der Klok, Rob J van Andel, Carola G M van Berkel, Marie Sissler, Joél Smet, Tatjana I Muravina, Sergey V Serkov, Graziella Uziel, Marianna Bugiani,…

  Nature genetics 2007 Apr

Associated Researchers

Thought leaders and organizations working on research involving leukoencephalopathy.

View All Authors

• Marjo S van der Knaap
• M S van der Knaap
• J C Pronk
• S Naidu
• Diana Rodriguez

View All Clinical Trials Sponsors

• Biogen Idec
• National Institute of Allergy and Infectious Diseases (NIAID)
• Massachusetts General Hospital
• Fred Hutchinson Cancer Research Center
• Glaxo Wellcome

View All Organizations

• National Institute of Neurological Disorders and Stroke
• Mayo Clinic
• Free University Medical Center
• Georg August University
• Vrije University Medical Center

Clinical Trials | 60 trials

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• The Nosology and Etiology of Leukodystrophies of Unknown Causes

  conditions: Leukodystrophy ; Leukoencephalopathy

  interventions: none

   

• A Study to Evaluate the Use of Cidofovir (an Experimental Drug) for the Treatment of Progressive Multifocal Leukoencephalopathy (PML) in AIDS Patients

  conditions: HIV Infections ; Leukoencephalopathy, Progressive Multifocal

  interventions: Cidofovir ; Probenecid

   

News | 59 stories

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• [Rapid Review] Natalizumab-associated progressive multifocal leukoencephalopathy in patients with multiple sclerosis: lessons from 28 cases

  Lancet. - March 15, 2010

• [Review] Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis

  Lancet. - March 15, 2010

Community

View All NextBio Users | 2 people

• Nahin  Hussain

• Sven  Thoms

NextBio Groups

• No NextBio groups were found for “leukoencephalopathy”.
  Be the first to start a group and share your interests with others within the NextBio community.

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