A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measure...

Data Correlations | 181 studies

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Genes	Score
HOXA9	100
PBX1	100
MYC	100
CTSG	100
LCK	100
TCL1A	100

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Biogroups	Score
Hematopoietic Cell Lineage	100
Natural Killer Cell Mediated Cytoto…	98
Cell Adhesion Molecules (CAMs)	97
B Cell Receptor Signaling Pathway	97
Immunoglobulin C1-set	97
Bcr Signaling Pathway	97

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Individual Studies

Comparative analysis of a CML cell line resistant to cyclophosphamide Homo sapiens |   RNA Expression Acquired imatinib resistance in chronic myelogenous leukemia (CML) can be the consequence of mutations in the kinase domain of BCR-ABL or increased protein levels. However, as in other malignancies, acquired resistance to cytostatic drugs is a common reason for treatment failure or disease progressi… Authors: Bao F, Polk P, Nordberg ML et al. Organization: LSU Health Sciences Center Medicine Divi…

Mouse tumors driven by various oncogenic factors Mus musculus |   RNA Expression Tumors driven by various oncogenes were compared against wildtype controls. Authors: Nevins JR Organization: Duke University IGSP 2133 CIEMAS, 101 Sc…

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Literature | 229,470 results

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• Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor.

  Authors: Matthew R Janes, Jose J Limon, Lomon So, Jing Chen, Raymond J Lim, Melissa A Chavez, Collin Vu, Michael B Lilly, Sharmila Mallya, S Tiong Ong,…

  Nature medicine 2010 Feb

• Germline genomic variants associated with childhood acute lymphoblastic leukemia.

  Authors: Lisa R Treviño, Wenjian Yang, Deborah French, Stephen P Hunger, William L Carroll, Meenakshi Devidas, Cheryl Willman, Geoffrey Neale, James Downing, Susana C Raimondi,…

  Nature genetics 2009 Sep

Associated Researchers

Thought leaders and organizations working on research involving leukemia.

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• James R Downing
• Teresa Palomero
• Iannis Aifantis
• Ching-Hon Pui
• Giuseppe Basso

View All Clinical Trials Sponsors

• Dana-Farber Cancer Institute
• M.D. Anderson Cancer Center
• Children's Cancer Group
• Fred Hutchinson Cancer Research Center
• Memorial Sloan-Kettering Cancer Center

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• St. Jude Children's Research Hospital
• University of Chicago
• Institute of Cancer Research
• University of California
• Stanford University School of Medicine

Clinical Trials | 3,544 trials

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• Banking of Chronic Lymphocytic Leukemia Tumor Cells for Vaccine Generation

  conditions: Chronic Lymphocytic Leukemia

  interventions: Leukemia cell harvest

   

• Collection and Banking of Leukemia Cells for Vaccine Generation in Patients With Advanced Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML)

  conditions: Myelodysplastic Syndrome ; Acute Myeloid Leukemia

  interventions: Collection of Leukemia Cells

   

News | 801 stories

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• Chinese Authorities Clear China Medical s Leukemia Diagnostic Kit

  Genetic Engineering & Biotechnology News.

• Gene 'addiction' of leukaemia cells

  News-Medical. - March 03, 2010

Community

View All NextBio Users | 18 people

• Steven  Paugh

• Abdul Rahman  El Kinge

  MD

  American University of Beirut Medical Center

NextBio Groups

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