A malignant (clonal) hematologic disorder, involving hematopoietic stem cells and characterized by the presence of primitive or atypical myeloid or lymphoid cells in the bone marrow and the blood. Leukemias are classified as acute or chronic based on the degree of cellular differentiation and the predominant cell type present. Leukemia is usually associated with anemia, fever, hemorrhagic episodes and splenomegaly. Common leukemias include acute myeloid leukemia, chronic myelogenous leukemia, acute lymphoblastic or precursor lymphoblastic leukemia, and chronic lymphocytic leukemia. Treatment is vital to patient survival; untreated, the natural course of acute leukemias is normally measure...

Data Correlations | 181 studies

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Genes	Score
HOXA9	100
PBX1	100
MYC	100
LCK	100
ATM	100
CTSG	100

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Biogroups	Score
Hematopoietic Cell Lineage	100
Natural Killer Cell Mediated Cytoto…	98
Cell Adhesion Molecules (CAMs)	98
B Cell Receptor Signaling Pathway	97
Immunoglobulin C1-set	97
Bcr Signaling Pathway	97

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Individual Studies

Comparative analysis of a CML cell line resistant to cyclophosphamide Homo sapiens |   RNA Expression Acquired imatinib resistance in chronic myelogenous leukemia (CML) can be the consequence of mutations in the kinase domain of BCR-ABL or increased protein levels. However, as in other malignancies, acquired resistance to cytostatic drugs is a common reason for treatment failure or disease progressi… Authors: Bao F, Polk P, Nordberg ML et al. Organization: LSU Health Sciences Center Medicine Divi…

Mouse tumors driven by various oncogenic factors Mus musculus |   RNA Expression Tumors driven by various oncogenes were compared against wildtype controls. Authors: Nevins JR Organization: Duke University IGSP 2133 CIEMAS, 101 Sc…

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Literature | 227,199 results

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• TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia.

  Authors: Kazuhito Naka, Takayuki Hoshii, Teruyuki Muraguchi, Yuko Tadokoro, Takako Ooshio, Yukio Kondo, Shinji Nakao, Noboru Motoyama, Atsushi Hirao

  Nature 2010 Feb 4

• Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras.

  Authors: Jennifer O Lauchle, Doris Kim, Doan T Le, Keiko Akagi, Michael Crone, Kimberly Krisman, Kegan Warner, Jeannette M Bonifas, Qing Li, Kristen M Coakley,…

  Nature 2009 Sep 17

Associated Researchers

Thought leaders and organizations working on research involving leukaemia.

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• Ching-Hon Pui
• James R Downing
• Giuseppe Basso
• Hong Wu
• Martin Schrappe

View All Clinical Trials Sponsors

• AstraZeneca
• Dana-Farber Cancer Institute
• PETHEMA Foundation
• Medical Research Council
• Assistance Publique - Hôpitaux de Paris

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• Institute of Cancer Research
• St Jude Children's Research Hospital
• University of California
• Columbia University
• Harvard University

Clinical Trials | 3,329 trials

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• Phase I AZD2171 in Patients With Relapsed or Refractory AML and Elderly Patients With DeNovo or Secondary AML

  conditions: Leukaemia ; Myelocytic ; Acute

  interventions: AZD2171

   

• Treatment of the Acute Myeloblastic Leukaemia in Patients Over 65 Years

  conditions: Acute Myeloblastic Leukaemia

  interventions: ARA-C ; Idarubicin ; Leucomax

   

News | 787 stories

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• Gene 'addiction' of leukaemia cells

  News-Medical. - March 03, 2010

• Plant flavanoid may help prevent leukemia

  Reuters. - January 28, 2010

Community

View All NextBio Users | 4 people

• Philippe  Guardiola

  Praticien Hospitalier

  University Hospital

• Fabio  Spiga

  Graduated

  University of Milan

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