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Description: A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat HIV disease. [PubChem]
Drug Type: Small Molecule; Approved; Investigational
Pharmacology: Lamivudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV). Lamivudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.
Mechanism of Action: Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination.
Indication: For the treatment of HIV infection and chronic hepatitis B (HBV).
Half Life: 5 to 7 hours
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Data Correlations | 3 studies

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Genes category icon Genes
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PCAF 100 100
PON1 100 100
CA3 97 97
CYP2E1 94 94
ARG1 93 93
FGF9 90 90
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Biogroups category icon Biogroups
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Antigen Dependent B Cell Activation 100 100
Dendritic Cells (DC) In Regulating … 100 100
T-helper 1/T-helper 2 Differentiati… 100 100
Bromodomain 99 99
Bystander B cell Activation 99 99
Neurotransmitter-gated ion-channel … 99 99
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Individual Studies

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    The DrugBank database is a unique bioinformatics and cheminformatics resource that combines detailed drug (i.e. chemical, pharmacological and pharmaceutical) data with comprehensive drug target (i.e. sequence, structure, and pathway) information.

    Authors: David S Wishart, Craig Knox, An Chi Guo et al.

    Organization: Department of Computing Science, Univers…

  • Liver Pharmacology and Xenobiotic Response Repertoire

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    A definition of RNA expression changes that correlate with liver response programs and an understanding of the similarities and differences in responses to different classes of chemicals would aid in new chemical or drug characterization and add to our understanding of liver biology.

    Authors: Natsoulis G, Pearson CI, Gollub J et al.

    Organization: Iconix Biosciences 325 E. Middlefield Rd…
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Associated Researchers

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Thought leaders and organizations working on research involving lamivudine.

View All Author iconAuthors
  • E Jenny Heathcote
  • Nancy Leung
  • Yun-Fan Liaw
  • Ching-Lung Lai
  • Stefan Zeuzem
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute of Allergy and Infectious Diseases (NIAID)
  • Idenix Pharmaceuticals
  • Bristol-Myers Squibb
  • National Institute of Diabetes and Digestive and Kidney Diseases (NIDD…
  • Glaxo Wellcome
View All Affiliations icon Organizations
  • University of Hong Kong
  • Chang Gung University College of Medicine
  • National Institute of Diabetes and Digestive and Kidney Diseases
  • University of Milan
  • Chang Gung Memorial Hospital

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