NextBio

Help
Description: A cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (receptors, N-methyl-D-aspartate) and may interact with sigma receptors. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Ketamine is a rapid-acting general anesthetic producing an anesthetic state characterized by profound analgesia, normal pharyngeal-laryngeal reflexes, normal or slightly enhanced skeletal muscle tone, cardiovascular and respiratory stimulation, and occasionally a transient and minimal respiratory depression. Ketamine is indicated as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation. The anesthetic state produced by Ketamine has been termed “dissociative anesthesia” in that it appears to selectively interrupt association pathways of the brain before producing somesthetic sensory blockade. It may selectively depress the thalamoneocortical system before significantly obtunding the more ancient cerebral centers and pathways (reticularactivating and limbic systems).
Mechanism of Action: Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system. Ketamine has been reported to produce general as well as local anaesthesia. It interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels. Unlike other general anaesthetic agents, ketamine does not interact with GABA receptors.
Indication: For use as the sole anesthetic agent for diagnostic and surgical procedures that do not require skeletal muscle relaxation.
Half Life: 2.5-3 hours.
View Complete Description



Data Correlations | 17 studies

Help for Data Correlations View All
Genes category icon Genes
Score Help
GRIN3A 100 100
View Top Genes

Individual Studies

  • Pregnant mice treated with Cocaine

    Mus musculus Mus musculus | RNA Expression   RNA Expression

    We explored the hypothesis that maternal cocaine exposure could alter the fetal epigenetic machinery sufficiently to cause lasting neurochemical and functional changes in the offspring.

    Authors: Novikova I Svetlana, He Fang, Bai Jie et al.

    Organization: University of Maryland Biomedical Scienc…

  • Brain from rats treated with chlorpyrifos

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    Chlorpyrifos is an organophosphorus insecticide that despite imposed restricitions on its use by the EPA, is one of the most commonly used insecticides. Although CPF is so widely used little is known about its effect on overall gene expression in vivo.

    Authors: Chan T Victor, Stapleton R Andrea

    Organization: Air Force Research Laboratory Applied Bi…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving ketamine.

View All Author iconAuthors
  • Celia J A Morgan
  • H Valerie Curran
  • Brigitta Brandner
  • Garry D Honey
  • Steven J Siegel
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Assistance Publique - Hôpitaux de Paris
  • Javelin Pharmaceuticals
  • Arkansas Children's Hospital Research Institute
  • Ullevaal University Hospital
  • Northwestern University
View All Affiliations icon Organizations
  • University College London
  • Yale University School of Medicine
  • Mount Sinai School of Medicine
  • National Institute of Mental Health
  • University of Pennsylvania

Clinical Trials | 121 trials

Help for Clinical Trials View All

News | 24 stories

Help for News View All

Community

Help for Community
NextBio Users

  • No NextBio users were found for “ketamine”.
    Complete your user profile with your interests, if you want others to find you within the NextBio community.

NextBio Groups

  • No NextBio groups were found for “ketamine”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio