NextBio

Help
Description: A stable, non-explosive inhalation anesthetic, relatively free from significant side effects. [PubChem]
Drug Type: Small Molecule; Approved
Pharmacology: Isoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential.
Mechanism of Action: Isoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Isoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Isoflurane also binds to the GABA receptor, the large conductance Ca2+ activated potassium channel, the glutamate receptor and the glycine receptor.
Indication: For induction and maintenance of general anesthesia.
View Complete Description



Data Correlations | 4 studies

Help for Data Correlations View All
Genes category icon Genes
Score Help
MT-ND1 100 100
KCNA1 100 100
ATP2C1 100 100
GABRA1 100 100
GLRA1 100 100
GRIA1 100 100
View Top Genes
Biogroups category icon Biogroups
Score Help
Heat shock protein DnaJ, N-terminal 100 100
Molecular chaperone, heat shock pro… 99 99
Major facilitator superfamily MFS-1 99 99
Major facilitator superfamily 98 98
Kelch related 97 97
Hedgehog Signaling Pathway 94 94
View Top Biogroups

Individual Studies

  • Genomics of the preconditioning of rat hearts

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    Comparisons were made of perfused rat hearts preconditioned by isoflurane or ischemia (ISH) and tested by ischemia and repurfusion, and control or non-preconditioned but ISH tested hearts.

    Authors: da Silva Rafaela, Lucchinetti Eliana, Pasch Thomas et al.

    Organization: Anesthesiology, University Hospital Zuri…

  • Effect of isoflurane on long term memory (LTM) of basolateral amygdala

    Rattus norvegicus Rattus norvegicus | RNA Expression   RNA Expression

    Fear conditioning in rats leads to long term memory (LTM) formation. A central neural substrate for LTM is the basolateral amygdala. We sought the expression changes specific to LTM at 6h following anesthesia with isoflurane (a general anesthetic and an effective amnestic agent), following pain (a c…

    Authors: Bell AH, Rampil IJ, Moller D

    Organization: University at Stony Brook Rampil Stony B…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving isoflurane.

View All Author iconAuthors
  • Jeffrey W Sall
  • Greg Stratmann
  • Ban Ku
  • Ran Dai
  • Laura d V May
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • National Institute on Drug Abuse (NIDA)
  • Duke University
  • Nanjing Medical University
  • University Health Network, Toronto
  • UPECLIN HC FM Botucatu Unesp
View All Affiliations icon Organizations
  • University of California
  • University of Virginia
  • Weill Cornell Medical College
  • Imperial College London
  • University of Chicago

Clinical Trials | 47 trials

Help for Clinical Trials View All

Community

Help for Community
View All NextBio Users | 1 person
  • Knut Wittkowski Knut  Wittkowski

    Head, Biostatistics, Epidemiology, and Research Design

    The Rockefeller University Center for Clinical and Translational Science

NextBio Groups

  • No NextBio groups were found for “isoflurane”.
    Be the first to start a group and share your interests with others within the NextBio community.

© 2010 NextBio