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Description: Iron dextran is a dark brown, slightly viscous liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. Iron Dextran is used for the treatment of patients with documented iron deficiency in which oral administration is unsatisfactory or impossible.
Drug Type: Small Molecule; Approved
Pharmacology: Iron dextran is a dark brown, slightly viscous sterile liquid complex of ferric hydroxide and dextran for intravenous or intramuscular use. It is for treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Iron is essential to the formation of hemoglobin and to the function and formation of other heme and nonheme compounds. Untreated depletion of iron stores leads to iron-deficient erythropoiesis and, in turn, to iron deficiency anemia.
Mechanism of Action: After iron dextran is injected, the circulating iron dextran is removed from the plasma by cells of the reticuloendothelial system, which split the complex into its components of iron and dextran. The iron is immediately bound to the available protein moieties to form hemosiderin or ferritin, the physiological forms of iron, or to a lesser extent to transferrin. This iron which is subject to physiological control replenishes hemoglobin and depleted iron stores.
Indication: For treatment of patients with documented iron deficiency in whom oral administration is unsatisfactory or impossible. Also used to replenish body iron stores in Non-Dialysis Dependent-Chronic Kidney Disease (NDD-CKD) patients receiving or not receiving erythropoietin and in Hemodialysis Dependent (HDD-CKD) and Peritoneal Dialysis Dependent (PDD-CKD) - Chronic Kidney Disease patients receiving an erythropoietin.
Half Life: 5 hours (some indications that it can be as long as 10 hours)
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FTL 100 100
TF 100 100
HBB 99 99
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Hemoglobin's Chaperone 100 100
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Thought leaders and organizations working on research involving iron dextran.

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  • Paul A Gulig
  • Rex Moats
  • Roslyn N Brown
  • Eric Peatman
  • Hans Goldenberg
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  • Oregon Health and Science University
  • Amgen
  • Pharmacosmos A/S
  • Massachusetts General Hospital
  • M.D. Anderson Cancer Center
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  • University of Florida College of Medicine
  • Medical College of Qingdao University
  • Children's Hospital of Los Angeles
  • University of Florida
  • Auburn University

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