NextBio

Help
Description: A metallic element found in certain minerals, in nearly all soils, and in mineral waters. It is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia.
Drug Type: Small Molecule; Approved
Pharmacology: The major activity of supplemental iron is in the prevention and treatment of iron deficiency anemia. Iron has putative immune-enhancing, anticarcinogenic and cognition-enhancing activities.
Mechanism of Action: Iron is necessary for the production of hemoglobin. Iron-deficiency can lead to decreased production of hemoglobin and a microcytic, hypochromic anemia.
Indication: Used in preventing and treating iron-deficiency anemia.
View Complete Description



Data Correlations | 6 studies

Help for Data Correlations View All
Genes category icon Genes
Score Help
YOR382W 100 100
PDXDC1 99 99
CLEC4M 98 98
Ifi202b 97 97
YAR010C 97 97
YOL101C 96 96
View Top Genes
Biogroups category icon Biogroups
Score Help
Pentose and Glucuronate Interconver… 100 100
Glycolysis Pathway 99 99
NAD(P)-binding 99 99
Lysine Degradation 98 98
PPAR Signaling Pathway 98 98
Short-chain dehydrogenase/reductase… 97 97
View Top Biogroups

Individual Studies

  • Hepatocellular Carcinoma Grade and Iron Homeostasis

    Homo sapiens Homo sapiens | RNA Expression   RNA Expression

    To improve the clinical management of human hepatocellular carcinoma (HCC) by accurate identification, at diagnosis, of patients at risk of recurrence after primary treatment for HCC

    Authors: Suk Mei Wang, London Lucien P J Ooi, Kam M Hui

    Organization: Bek Chai Heah Laboratory of Cancer Genom…

  • Aft1 and aft2 mutation in iron depleted conditions

    Saccharomyces cerevisiae Saccharomyces cerevisiae | RNA Expression   RNA Expression

    Transcriptional effect of aft1 and aft2 mutation in iron depleted conditions.

    Authors: Courel Maïté, Camadro Jean-Michel, Blaiseau Pierre-Louis

    Organization: Institute Jacques Monod Protein Engineer…
View All Individual Studies

Associated Researchers

Help for Associated Researchers

Thought leaders and organizations working on research involving iron.

View All Author iconAuthors
  • Roland Lill
  • Fudi Wang
  • Nancy C Andrews
  • Des R Richardson
  • Jerry Kaplan
View All Clinical trial sponsors icon Clinical Trials Sponsors
  • Novartis
  • Novartis Pharmaceuticals
  • Eunice Kennedy Shriver National Institute of Child Health and Human De…
  • Pharmacosmos A/S
  • Vifor Inc.
View All Affiliations icon Organizations
  • Washington University School of Medicine
  • Philipps-Universität Marburg
  • Naval Research Laboratory
  • Institute for Solid State Research
  • Stanford University

Clinical Trials | 1,056 trials

Help for Clinical Trials View All

News | 340 stories

Help for News View All

© 2010 NextBio