An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated lipid rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction.

Data Correlations | 1,332 studies

View All

Normal tissues	Score
Mesenteric lymph nod…	100
Thymus	88
Cecum	84
Zone of stomach	80
Superior surface of …	78
Subdivision of nucle…	76

View Top Normal tissues

Compounds	Score
Bute Hydrocarbon	100
Zinc Ion	96
Phytol	96
Butyric Acid	91
Crystalbumins	90
Gamma Rays	89

View Top Compounds

Diseases	Score
Systemic inflammator…	100
cancer of ileum	97
Septic shock	97
Aseptic necrosis of …	95
Smallpox	94
Primary cutaneous ma…	94

View Top Diseases

Individual Studies
Pluripotent stem cells induced from bone marrow PBMCs score: 100 | Mus musculus |   RNA Expression Here we show that mouse adult BM mononuclear cells（BM MNCs）are competent as donor cells and can be reprogrammed into pluripotent ES cell-like cells. Source: NextBio Library/Stem Cells, Differentiation & Development	Normal blood cell subtypes; comparison of subtypes score: 98 | Homo sapiens |   RNA Expression CD4+ T cells, CD8+ T cells, and B cells were compared to whole blood and PBMCs. Authors: Palmer Chana Organization: Stanford Microarray Database (SMD) Stanf…

View All Individual Studies

Literature | 1,276 results

View All

• Immunological synapse formation inhibits, via NF-kappaB and FOXO1, the apoptosis of dendritic cells.

  Authors: Lorena Riol-Blanco, Cristina Delgado-Martín, Noelia Sánchez-Sánchez, Luis M Alonso-C, María Dolores Gutiérrez-López, Gloria Martínez Del Hoyo, Joaquín Navarro, Francisco Sánchez-Madrid, Carlos Cabañas, Paloma Sánchez-Mateos,…

  Nature immunology 2009 Jul

• Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.

  Authors: Katrina L Randall, Teresa Lambe, Andy Johnson, Bebhinn Treanor, Edyta Kucharska, Heather Domaschenz, Belinda Whittle, Lina E Tze, Anselm Enders, Tanya L Crockford,…

  Nature immunology 2009 Dec

Associated Researchers

Thought leaders and organizations working on research involving immunological synapse.

View All Authors

• Michael L Dustin
• Mark M Davis
• Salvatore Valitutti
• Johannes B Huppa
• Gillian M Griffiths

View All Organizations

• Washington University School of Medicine
• New York University School of Medicine
• Stanford University School of Medicine
• Sir William Dunn School of Pathology
• University of California

Community

NextBio Users

• No NextBio users were found for “immunological synapse”.
  Complete your user profile with your interests, if you want others to find you within the NextBio community.

NextBio Groups

• No NextBio groups were found for “immunological synapse”.
  Be the first to start a group and share your interests with others within the NextBio community.

search → result

search → result