A malignant tumor that arises from hepatocytes. Hepatocellular carcinoma is relatively rare in the United States but very common in all African countries south of the Sahara and in Southeast Asia. Most cases are seen in patients over the age of 50 years, but this tumor can also occur in younger individuals and even in children. Hepatocellular carcinoma is more common in males than females and is associated with hepatitis B, hepatitis C, chronic alcohol abuse and cirrhosis. Serum elevation of alpha-fetoprotein occurs in a large percentage of patients with hepatocellular carcinoma. Grossly, hepatocellular carcinoma may present as a single mass, as multiple nodules, or as diffuse liver invol...

Data Correlations | 26 studies

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Genes	Score
FOXM1	100
CDKN1A	100
TXNIP	100
APC	100
NFE2L1	100
CTNNB1	100

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Biogroups	Score
Cytochrome P450 Protein Family	100
Cytochrome P450, E-class, group I	100
Metabolism of Xenobiotics by Cytoch…	100
Gamma Hexachlorocyclohexane Degrada…	99
Fatty Acid Metabolism	99
Bile Acid Biosynthesis	98

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Individual Studies

Hepatocellular Carcinoma Grade and Iron Homeostasis Homo sapiens |   RNA Expression To improve the clinical management of human hepatocellular carcinoma (HCC) by accurate identification, at diagnosis, of patients at risk of recurrence after primary treatment for HCC Authors: Suk Mei Wang, London Lucien P J Ooi, Kam M Hui Organization: Bek Chai Heah Laboratory of Cancer Genom…

Genome wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma Homo sapiens |   RNA Expression Gene expression profiles of 75 tissue samples were analyzed representing the stepwise carcinogenic process from pre-neoplastic lesions (cirrhosis and dysplasia) to HCC, including four neoplastic stages (very early HCC to metastatic tumors) from patients with HCV infection. Gene signatures that accur… Authors: Wurmbach E, Chen Y, Khitrov G et al. Organization: Mount Sinai School of Medicine Hematolog…

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Literature | 65,024 results

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• Mst out and HCC in.

  Authors: Bin Zhao, Qunying Lei, Kun-Liang Guan

  Cancer cell 2009 Nov 6

• Expression pattern, regulation, and functions of methionine adenosyltransferase 2beta splicing variants in hepatoma cells.

  Authors: Heping Yang, Ainhoa Iglesias Ara, Nathaniel Magilnick, Meng Xia, Komal Ramani, Hui Chen, Taunia D Lee, José M Mato, Shelly C Lu

  Gastroenterology 2008 Jan

Associated Researchers

Thought leaders and organizations working on research involving hepatoma.

View All Authors

• Josep M Llovet
• Augusto Villanueva
• Jane A McKeating
• Hashem B El-Serag
• Peter Balfe

View All Clinical Trials Sponsors

• National Taiwan University Hospital
• National Health Research Institutes, Taiwan
• Memorial Sloan-Kettering Cancer Center
• Tularik
• Massachusetts General Hospital

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• University of Birmingham
• Mount Sinai School of Medicine
• University of Tokyo
• Chang Gung Memorial Hospital
• University of Michigan Medical Center

Clinical Trials | 774 trials

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• SIR-Spheres® for the Treatment of Unresectable Hepatocellular Carcinoma

  conditions: Carcinoma, Hepatocellular ; Hepatoma

  interventions: SIR-Spheres microspheres

   

• Study of Sorafenib and Transarterial Chemoembolization (TACE) to Treat Hepatocellular Carcinoma

  conditions: Hepatocellular Carcinoma ; Hepatoma

  interventions: sorafenib ; LC Bead-TACE

   

News | 86 stories

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• Health Matters : What is a Hepatoma ?

  PR-inside.com. - November 06, 2009

• Feasible And Safe Treatment For Recurrent Hepatocellular Carcinoma In Elderly Patients

  Medical News Today. - February 06, 2010

Community

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  Laboratory Manager

  Netria Limited

• Jennifer  Hurst-Kennedy

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